chronic kidney disease, pathophysiologyBackground: The uremic syndrome is characterized by a complex clinical picture, whereby the function of multiple organ systems is affected by the retention of a host of solutes. Recent research of the last decade has helped to unravel multiple pathophysiologic ...
Identify and explain the fluid and electrolyte changes in chronic kidney disease. Explain which disturbances a person with chronic kidney disease may be experiencing. A patient with a bleeding tendency has a prolonged partial thromboplastin time with a normal prothro...
Chronic kidney disease is identified clinically by a reduction in glomerular filtration rate (GFR) and has been characterized histologically by nephrosclerosis. Many relatively healthy older adults have been diagnosed with chronic kidney disease because of a decline in GFR with normal aging. Recent ...
Inflammatory processes have been suggested as a potential pathophysiological mechanism underlying the development of several major chronic diseases, including cardiovascular, metabolic and psychotic disorders1. Systemic inflammation is also one of the most studied pathways in the context of the social-to-bio...
(2017) showed that present biasedness was associated with earlier onset of diabetes and lower ability to manage chronic disease. This supports the development of interventions aiming to mitigate the effect of this bias (e.g. incentives or monetary-based rewards) to increase adherence to self-...
A detailed review of the maternal medical history was significant for receiving a kidney transplant from a male donor.28 Presumably, the circulating Y chromosome fragments derive from low-level chronic rejection of the transplanted kidney, resulting in cell death.29 In another case,30 a 36-year-...
(ACE1), have been associated with numerous comorbidities, such as cardiovascular disease, hypertension, diabetes, chronic kidney disease, and obesity, and there are potential mechanisms to explain these associations (e.g., DD-type carriers have greater ACE1 activity, and patients with a genetic ...
For people with diabetes, when sugar remains high in the bloodstream for long periods of time, “it can cause damage to the tiny vessels throughout our body, such as those in the eyes, kidney, heart and even our fingers and toes,” says Cooke. “This is when we see some of the long...
Polymorphisms of genes, such as those that encode angiotensin-converting enzyme 1 (ACE1), have been associated with numerous comorbidities, such as cardiovascular disease, hypertension, diabetes, chronic kidney disease, and obesity, and there are potential mechanisms to explain these associations (e.g...
Introduction Although current therapies have made HIV-1-induced acquired immune deficiency syndrome (AIDS) a manageable chronic disease, it remains a global health priority. The unavailability of a cure and the development of drug resistance indicate that a deep understanding of all steps of the HIV...