Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....
This result extends the previous findings on linear regression46 to the large class of rotation invariant kernels. (5) When all stages are considered, it is possible to observe learning curves with multiple descents with at most one peak per stage. The presence and size of the descent peak...
Moreover, they cannot easily anticipate the questions posed by anonymous investors.10 The openness and anonymity increase the likelihood that investors’ questions reflect their common concerns. 2.2.4. Enforcement SSE strived to enforce compliance with the regulation. The exchange issued several notices ...
Function objects don't even have to be declared with a name - you can write an anonymous function definition directly into the arguments of another. setTimeout(function(){ console.log("It's been 5 seconds!"); // this code will be called in 5 seconds time }, 5000); This has led to...
The mechanism of human immunodeficiency virus 1 (HIV-1) nuclear entry, required for productive infection, is not fully understood. Here, we report that in HeLa cells and activated CD4+ T cells infected with HIV-1 pseudotyped with VSV-G and native Env pro