Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....
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Comparing to a generic two-state model, our models can distinguish class I from class II MHCs and correlate their structural parameters with the TCR/pMHC’s potency to trigger T cell activation. The models are tested by mutagenesis using an MHC and a TCR mutated to alter conformation changes....
(NAEOTOM Alpha, SOMATOM Force, SOMATOM Definition AS, SOMATOM Edge Plus, Cardiac64 or SOMATOM Definition Flash; Siemens Healthcare, Forchheim, Germany and Brilliance 16P, Philips, Amsterdam, The Netherlands) with or without the application of an intravenous contrast agent in supine position at full...
The receptor copy of peptide A oligomerizes with a peptide B that functions to anchor the protoreceptor A + B into the lipid membrane (represented by the gray dots and vertical lines), and this proto-receptor is able to bind the peptide A ligand copy. (b) Root-Bernstein’s extension of...