The data showed that infusion of autologous HER2-CAR VSTs is safe and can be associated with clinical benefit for patients with progressive GBM [124]. In 2017, the results of a first-in-human clinical trial (NCT02209376) of CART-EGFRvIII in 10 patients with recurrent EGFRvIII-positive GBM ...
have used VSTs with a co-stimulatory CAR (CoCAR), which lacks the CD3ζ domain. Thus, the CoCAR is responsible for inducing co-stimulatory signals, when it detects the target antigen, and a survivin-specific transgenic TCR is responsible for the first signal of T cell activation. In this ...
which has also reached to phase III clinical trials. A phase I study demonstrated the safety of ICT-107 with a suggestion of benefit to patients who were HLA-A2 positive [164]. A phase II trial showed that ICT-107 has some therapeutic activity in HLA-A2 positive patients and led to ...