Focused ultrasound therapy Despite incremental advances in the therapeutic approach to GBM, there has been minimal development of both new and existing drug therapies for recurrent GBM [6]. The last drug to significantly improve OS for GBM was TMZ, which was introduced 20 years ago [35]. Aft...
have used VSTs with a co-stimulatory CAR (CoCAR), which lacks the CD3ζ domain. Thus, the CoCAR is responsible for inducing co-stimulatory signals, when it detects the target antigen, and a survivin-specific transgenic TCR is responsible for the first signal of T cell activation. In this ...