Breast cancer (BC) is the most common prevalent lethally neoplastic condition in females [1]. In most circumstances, the rate of cellular and molecular heterogeneity is high in BC because of the distinct genomic and proteomic signatures of tumor cells. These features lead to the emergence of dif...
Breast cancer (BC) is a prevalent and highly lethal cancer in females. Like other cancer types, the intricate cellular and molecular heterogeneity leads to the variation of therapeutic outcomes. The development and progression of blood vessels increase t
Wu, CY., Du, SL., Zhang, J.et al.Exosomes and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment.Cancer Gene Ther24, 6–12 (2017). https://doi.org/10.1038/cgt.2016.69 Received19 June 2016 ...
Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer. Mol Cancer 2014; 13: 256. Article CAS Google Scholar Shi J, Ren Y, Zhen L, Qiu X . Exosomes from breast cancer cells stimulate proliferation and inhibit apoptosis of CD133+ cancer cells in vitro. Mol Med Rep...
Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal tr...
Improved treatment of breast cancer, the world's second most common cancer, requires identification of new sensitive prognostic and diagnostic biomarkers. Exosomes are lipid-bilayer extracellular vesicles of size 30–150 nm, released by all cell types, including breast cancer cells. Cellular communicatio...
(HCC), pancreatic cancer and breast cancer [7]. Exosomes with higher expression of phosphatidylserine [76], migration inhibitory factor [4], and miRNA183-5p [8] are able to convert the surrounding phagocytes into TAMs and increase the inflammatory cytokine production. Furthermore, TEXs not ...
Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. There...
Villagrasa A;Alvarez PJ;Osuna A;.Exosomes de- rived from breast cancer cells,small Trojan horses?.JMammary Gland Biol Neoplasia.2014.303-313Villagrasa A, Alvarez PJ, Osuna A, Garrido JM, Aranega A, and Rodriguez-Serrano F (2014). Exosomes derived from breast cancer cells, small trojan ...
Exosomes and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment The discussion would focus on the role of exosomes in breast cancer development, progression, metastasis and drug resistance, as well as related therapeutic and diagnostic strategies.Cancer Gene...