Non-small cell lung cancer (NSCLC) remains an ongoing health concern, with poor treatment options and prognosis for many patients. Typically, individuals with lung cancer are detected at the middle and terminal stages, resulting in poor medical results due to lack of initial diagnosis and treatment...
Another factor limiting the therapeutic efficacy of chemotherapeutic agents is multi-drug resistance (MDR), which may originate from congenital or acquired acquisition. The presence of MDR reduces the tumor response rate to treatment and leads to the death of over 90% of patients with cancer receivi...
Focusing on exosomal circUPF2 could potentially be an innovative approach for HCC treatment. Graphical AbstractIntroduction Hepatocellular carcinoma (HCC) is the most common prevalent liver tumor, with an estimated incidence of over one million cases by 2025 [1, 2]. Less than 30% of patients ...
inflammation-related genes25. Super-repressor IκB, a S32A and S36A mutant form of IκB, is not phosphorylated by IκB kinases, so that srIκB suppresses the translocation of NF-κB complex even in the presence of pro-inflammatory stimulation26. As expected, treatment with srIκB-mCherry:...
Using experimental models of BPD, we (36) and others (37) have shown that MSC treatment blunts hyperoxia-induced lung inflammation, improves lung architecture, ameliorates vas- cular remodeling, improves exercise capacity, and increases survival rates. Promising preclinical data (reviewed in ref. (...
Treatment of HSCs with serum-derived exosomes induced a prominent activation of AKT signaling within 15 min (Fig. 2A). This time point is consistent with previous publications (41), prompting us to use a 15-min time point for the remainder of our experiments examining AKT phosphorylation. In ...
(B) Representative plot of EL-associated median GFP fluorescence intensity over time (min), corrected by cytoplasmic GFP background subtraction; (+), dimerizer (gray); (−), dimerizer (red) treatment. Slope A characterizes the near-linear GFP decay. Only loss of GFP signal in MVBs is qu...
Non-small cell lung cancer (NSCLC) remains an ongoing health concern, with poor treatment options and prognosis for many patients. Typically, individuals with lung cancer are detected at the middle and terminal stages, resulting in poor medical results due to lack of initial diagnosis and treatment...
In the near future, remarkable advances in exosome engineering and cargo-loading approaches are expected, enabling precise and targeted delivery of therapeutic mRNAs for the treatment of various diseases. Using autologous exosomes for therapeutic drug delivery is expected to mitigate uncertain immunogenicity...
In this context, it has been shown that EGF treatment specifically upregulates ESCRT-dependent ILV formation41. Here we show that ARF6 controls EGFR late endosomal sorting as its depletion results in increased cellular EGFR and in a lack of EGFR degradation upon EGF stimulation. In ARF6-...