For example, highly metastatic HCC cell-secreted exosomal miR-1247-3p directly targets B4GALT3 to activate β1-integrin-NF-κB signaling in fibroblasts, thus increasing the ability of normal fibroblasts to transform into CAFs40. In addition, exosomal miRNA-105, which is characteristically expressed...
Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2 Article Open access 28 July 2021 Introduction Lung cancer is a leading cause of cancer deaths among both men and women, and non-small-cell lung cancer (NSCLC) accounts for 80...
The functions of miR-200b-3p exosomes were confirmed using in vitro and in vivo assays. The interactions between microRNAs and ZEB1 as well as cancer cells and macrophages were measured using RNA pull-down and luciferase gene reporter assays.Results Using in silico analysis, we identified high ...
miR-106b-5p is enriched in melanoma cell-secreted exosomes and transferred to melanocytes. Exosomal miR-106b-5p promotes the epithelial-to-mesenchymal transition (EMT), migration, invasion and adhesion of melanocytes. Exosomal miR-106b-5p exerted its role by targeting EphA4 to activate the ERK ...
MiR-200b in heme oxygenase-1-modified bone marrow mesenchymal stem cell-derived exosomes alleviates inflammatory injury of intestinal epithelial cells by targeting high mobility group box 3. Cell Death Dis. 2020;11(6):480. Article CAS PubMed PubMed Central Google Scholar Niu L, Yang W, Duan...
Barroso-delJesus A, Romero-Lopez C, Lucena-Aguilar G, Melen GJ, Sanchez L, Ligero G, Berzal-Herranz A, Menendez P: Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol. 2008, 28 (21): 6609-6619. 10.112...
Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth Exosomes are extracellular vesicles that are released from cells and comprise microRNAs (miRNAs); however, little is known about the homogeneity of their contents. In this ...
Jingyue Yang bJunjie Li cBen Ma aJianlin Wang aXisheng Yang aMeng Pu aCancer LettersZhang Z, Li X, Sun W et al. Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis. Cancer Lett 2017;397:33-42....
Exosomal SENP3-EIF4A1 can be transferred into HCC cells thus inhibiting tumor cell growth, and attenuate invasion and migration of HCC cells,231 while exosomal linc-FAM138B plays a role in repressing HCC growth by targeting miR-765.232 Exosomal circRNAs play a role in cellular processes of HCC...
(miR-148a-3p,miR-451a, andmiR-150-5p) with differential PE expression between the TB group and the other benign lesions group, while nine exosomal miRNAs (miR-205-5p,miR-483-5p,miR-375,miR-200c-3p,miR-429,miR-200b-3p,miR-200a-3p,miR-203a-3p, andmiR-141-3p) in the PE ...