In this review, we will cover the immunosuppressive role of exosomal PD-L1 (ExoPD-L1), ExoPD-L1 regulatory factors and emerging approaches for quantifying and detecting ExoPD-L1. More importantly, we will discuss how targeted ExoPD-L1 and combination therapy can be use...
Recently, PD-L1 levels on tumor cell exosomes showed the potential to predict ICB response. Here, we developed a non-invasive, sensitive, and fast assay, termed as exosome-hybridization chain reaction (ExoHCR), to analyze tumor cell exosomal PD-L1 levels. First, using αCD63-conjugated ...
图1 糖基化外泌体PD-L1检测方法及流程 最后研究纳入了27例临床样本(13例肿瘤患者,14例健康对照),采用PD-L1适配体+凝聚素ConA亲和探针量化糖基化exoPD-L1水平,发现与与健康对照相比,癌症患者的糖基化 exoPD-L1 水平与显著升高(p < 0.0001)(图2A),ROC分析显示糖基化外泌体PD-L1水平可显著区分健康供体和癌...
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PDL-1 is abundantly present on tumor cells and interacts with PD-1 on activated T cells, resulting in T cell suppression and allowing immune evasion of cancer cells. Various FDA-approved monoclonal antibodies inhibiting the PD-1/PD-L1 interaction are commonly used ...
Migrations were more reduced in the tepotinib-treated group than in the control group.Conclusions:These data show the possibility that tepotinib may have therapeutic effects in c-MET-amplified GC and both high PD-L1 expression and an MET exon 14 skipping mutation, suggesting that clinical ...