O4: Potential to instill process-oriented governance in an organization’s “DNA.” The implementation of new governance setups may facilitate transformation toward a truly process-oriented organization. Currently, many organizations feature BPM roles and responsibilities that are formally described but not...
AFN-1252 caused a dose-dependent inhibition of fatty acid synthesis in growing Neisseria, a delayed inhibition of growth phenotype, and minimal inhibition of DNA, RNA, and protein synthesis, showing that its mode of action is through inhibiting fatty acid synthesis. Isotopic fatty acid labeling ...
In other embodiments, the cells are stably transfected, i.e., the exogenous nucleic acid is integrated into the host cell's chromosomal DNA. The term “exogenous” as used herein with reference to a nucleic acid and a particular cell refers to any nucleic acid that does not originate from ...
The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic effects in multiple organs including brain, heart, and skeletal muscle by serving as an alternative substrate for energy provision, and by modulating inflammation, oxidative stress, catabolic processes, and gene express...
However, fewer than 30 reads for miR393a-3p and miR829-3p were found in the four libraries, meaning that they were expressed at a low level. Furthermore, the expression of members in the same family usually considered to be similar may also be very different. For example, in the miR...
The Effect of Exogenous Nitric Oxide on Neuronal Zn 2+ Homeostasis Plug-and-Produce (with the meaning that devices can be plugged in without any manual configurations needed) is an attractive paradigm for manufacturing systems, and in particular for Small and Medium Enterprises (SMEs) that do ...
has been delayed because of safety considerations. Integration of exogenous DNA into the genome of a cell can cause DNA damage and possible genetic changes in the recipient cell that could predispose it to malignancy. A method which avoids these potential problems would be of significant...
The strains according to the invention can be generated by any appropriate method. The skilled person knows, for example, multiple methods for introducing a gene into a yeast strain, in particular through the use of vectors comprising expression cassettes. “Vector” means any DNA sequence into wh...
which uses a DNA fragment comprising a certain known sequence to undergo homologous recombination with a gene with the same or similar sequence in the genome of the recipient cell, so that it integrates into the genome of the recipient cell and is expressed. It ...
The following definitions are set forth to illustrate and define the meaning and scope of the various terms used to describe the invention herein. A“nucleic acid or polynucleotide sequence” includes, but is not limited to, eucaryotic mRNA, cDNA, genomic DNA, and synthetic DNA and RNA sequence...