wkq-13345 中文名称:艾塞那肽 英文名称:Exendin-4 英文别名:Exendin 3 (Heloderma horridum),2-glycine-3-L-glutamic acid-;Exendin 4 (Heloderma suspectum) (9CI);L-Histidylglycyl-L-α-glutamylglycyl-L-threon
Motor function evaluation with the Basso Beattie Bresnahan (BBB) locomotor rating scale indicated significantly increased scores (p<0.01) in the Ex-4-treated groups, especially 10g, which demonstrated the neuroprotective effect of Ex-4 after SCI. The light chain 3-II (LC3-II) and Beclin 1 ...
每组小鼠在给予Exendin-4及Exendin-4类似物之前,测初始血 糖值,定为-30min,然后腹腔给予Exend in-4类似物,30min后腹腔注射葡萄糖(每千克 18mmol ),定为Omin,对照组注射相同体积的生理盐水和Exendin-4aOmin,15min,30min, 60min,90min,120min分别尾部取血,测定血液葡萄糖浓度。并且于360min和720min再次注 射...
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, exerts cell-protective effects on many types of cells. However, little information is available regarding the influence of Ex-4 on MSC. In our study, MSC were isolated from bone marrow and cultured in vitro. After treatment ...
Exendin-4-Fc融合蛋白是一种长效降糖药,是通过基因手段将功能Exendin-4 Fc通过特异性的链接肽与IgG2亚型抗体的Fc融合研制成新一代GLP-1类似物,优于目前上市的GLP-1药物,对已上市GLP-1药物具有替代效应(目前上市的几款GLP-1长效降糖药一般是每日/周一次,而Exendin-4-Fc融合蛋白理论上是可每两周注射一次),2018...
Exendin-4 (Ex-4) is an anti-diabetic drug that is a potent agonist of the glucagon-like peptide-1 (GLP-1) receptor. It has already been approved for the treatment of type 2 diabetes mellitus, but its underlying mechanisms of action are not fully understood. Calcium/calmodulin-dependent ser...
本发明一方面,提供了一种Exendin-4类似物融合蛋白(以下简称融合蛋白),所述融合蛋白从N端到C端依次含有Exendin-4类似物(表示为Ex(1-45)),肽接头(Linker,表示为L)和人IgG2Fc变体(表示为vFc),融合蛋白可表示为Ex(1-45)-L-vFc; 其中,所述Exendin-4类似物Ex(1-45)为COOH末端修饰的Exendin-4,即在第39位Ser...
3 Exendin-4的功能Exend 11、in-4首先翻译成 N 端多余45个氨基酸残基的前体,然后在激素原转化酶的催化下分解产生具有生物活性的 Exendin-4。Exendin-4的N端是一段不规则卷曲,第7-28 氨基酸残基形成 螺旋,C 端是不规则亲水片断。Exendin-4 的受体是 G 蛋白,N 端是激活受体信号传导途径的关键区域,中间部位和...
本发明一方面,提供了一种Exendin-4类似物融合蛋白(以下简称融合蛋白),所述融合蛋白从N端到C端依次含有Exendin-4类似物(表示为Ex(1-45)),肽接头(Linker,表示为L)和人IgG2Fc变体(表示为vFc),融合蛋白可表示为Ex(1-45)-L-vFc; 其中,所述Exendin-4类似物Ex(1-45)为COOH末端修饰的Exendin-4,即在第39位Ser...
Exendin-4及2型糖尿病心血管并发症 河北医科大学 硕士学位论文 Exendin-4与2型糖尿病心血管并发症 姓名：张坤 申请学位级别：硕士 专业：内科学 指导教师：王瑞英 20090301