Moreover, we measured the spatial variability of transsynaptic alignment in these synapse types, revealing protein alignment in Ex→PV synapses over a distinct range of distances compared to Ex→Ex synapses. We conclude that while general principles of nanostructure and alignment are shared, cell-...
Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathwayNeuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathwayNeuroplastin 65Learning and memoryAnxiety...
Note that the ~1 µm extent of the iGluSnFR transients is the same size as the expected point spread function; therefore, this size should be considered an upper limit to the detected spread of glutamate beyond the synapse; the actual spread may be <1 µm. Reporting summary ...
In vivo selective deletion of GDF11 in the EN affects the transcription of both the excitatory and the inhibitory synapse assembly related genes (Supplementary Fig. 12). The most upregulated Abi3bp triggers cellular senescence through p21 pathway35, and Wnt7a is an inducer of beta-catenin-indep...
Indeed, each NT has a fundamentally distinct receptor so even within one class of neurotransmission (excitatory vs. inhibitory), strategies that label one receptor necessarily omit others. There is a strong need for general cell-type-specific excitatory and inhibitory postsynaptic labels. Further, ...
There are comments on PubPeer for publication: Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models (2022)
This suggests a specific increase in excitatory synapse turnover after repetitive concussions that is not seen after a single concussion and does not occur for inhibitory inputs. We also show that these changes occur not only in the cortical region underlying the impact but also in regions of ...
Estradiol (E2) perfusion rapidly increases the strength of fast excitatory transmission and facilitates long-term potentiation in the hippocampus, two effects likely related to its memory-enhancing properties. Past studies showed that E2’s facilitation
Bath infusion of nimodipine (10 μM, 20 min) failed to produce any inhibitory effect on the slope of fEPSP re- corded from the superficial layer of the ACC slice (end of drug: 101.2 ± 3.3%, end of experiment: 99.2 ± 2.3%, n = 5 slices/5 mice; Figure 3G and H). Similar ...
After reaching the parental dendritic shafts, synapse translocation is downregulated (Fig. 8d). Mixed polarity of microtubules in the parental dendritic shafts27 may suppress directional mobility of synapses. PSD maturation enhances NMDA receptor-dependent calcium influx28, which may also negatively ...