Surprisingly, with further cell-type specific analysis and manipulation, we also observed that methamphetamine-associated memory retrieval activated inhibitory neurons in the mPFC to facilitate memory reconsolidation, while suppressing excitatory neurons to aid memory expression. These findings provide novel ...
Syt1 KO neurons exhibited an ∼3-fold increase in the frequency of both mEPSCs and mIPSCs, consistent with syt1’s previously reported function as an inhibitory clamp of spontaneous fusion (mEPSCs: syt1 WT: 2.8 ± 0.5 Hz, n = 16; syt1 KO: 9.7 ± 1.2 Hz, n = 18, p < 0.001;...
We also strike a balance between the excitatory and inhibitory mechanisms of neurons to dynamically control the output of spiking neurons. By combining these two mechanisms, we propose a deep SNN with adaptive self-feedback and balanced excitatory and inhibitory neurons (BackEISNN). The results of...
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors, including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of functions ascribed to the LHA may be explained by a heterogeneous population of neurons, the full diversity of which is poorly ...
Excitatory and inhibitory inputs from utricular afferents to cat single vestibular neuronsUchino, Y.Sato, H.Ogawa, Y.Kushiro, K.Zakir, M.Imagawa, M.Katsuta, M.Isu, N.EXCERPTA MEDICA INTERNATIONAL CONGRESS SERIES
Schneggenburger R, Lopez-Barneo J, Konnerth A. Excitatory and inhibitory synaptic currents and receptors in rat medial septal neurons. J Physiol 1992;445:261-76.Schneggenburger R, L opez-Barneo J, Konnerth A (1992) Excitatory and inhibitory synaptic currents and receptors in rat medial septal...
phosphorylation in hippocampal excitatory neurons and a subset of hippocampal inhibitory neurons (those that express somatostatin, but not parvalbumin). Moreover, ablation of p-eIF2α in either excitatory or somatostatin-expressing (but not parvalbumin-expressing) inhibitory neurons increased general mRNA ...
The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal and glial cell types. Cortical neurons can be broadly categorized into two classes—excitatory neurons that use the neurotransmitter glutamate, and inhibitory i
Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice Shi-Ge Xue, Jin-Gang He, Ling-Li Lu, Shi-Jie Song, Mei-Mei Chen, Fang Wang & Jian-Guo Chen Nature Communications volume 14, Article number: 7971 (2023)...
We used virus-mediated manipulation of DBI expression in the embryo and investigated the effect on proliferation in the neocortex and the GEs. The in vivo approach allowed us to study the long-term effect on the number of excitatory and inhibitory neurons in the juvenile brain. We identified ...