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First, a primer on dopamine Dopamine, also known as one of the feel-good hormones, is a neurotransmitter that acts as part of your brain’s reward system. Whereas dopamine was previously thought to provide us with pleasure,researchhas found that the chemical itself doesn’t make you happy. ...
Ethanol has not been shown to interact directly with SigRs, but SigRs ligands may alter reinforcing actions of ethanol by indirectly modulating activity of other ethanol- sensitive transmitter systems; for example, SigR ligands affect synthesis, release, and uptake of dopamine (Bastianetto et al,...