Under-reporting of clinical trials is unethical. Lancet 361: 978–979. https://doi.org/10. 1016/S0140-6736(03)12838-3. Arnqvist, G., and D. Wooster. 1995. Meta-analysis: Synthesizing research findings in ecology and evolution. Trends in Ecology and Evolution 10: 236–240. https://...
Human Body Exhibition: Unethical Actions on Human Remains Back to top I Impacts of raising minimum wage in California Impact of Affordable Care Act on Community Health Nursing Impact of Corporate Reputation on Organizational Performance Impact of Violent Movies on Children’s Behaviors Impleme...
However, there are some scenarios where randomizing subjects to a control group would be imprac- tical or unethical, such as a clinical trial of a treatment for a serious condition where there is a moral argument against giving participants a placebo but there is no existing standard of care...
If the effect observed in mice reproduces in humans at the same rate (68% improvement in treat/diet patients; 3.7% in control diet), the study could be stopped after 11 patients/group, because it would be unethical to not treat controls with the beneficial diet. However, if control diet...
Note that due to ethical considerations, placebos are not always used in clinical trials. For example, as it would be unethical to leave terminal cancer patients untreated, placebos aren’t used in these types of studies. What is the definition of placebo effect? For some people, just the ...
Reputational damage from being associated with unethical companies, controversial projects or other industries with high ESG risks. Stringent regulatory requirements that can cause compliance problems for financial institutions. Failing to meet the needs of underserved communities and provide equitable access ...
Healthcare providers aren't allowed to use placebos in actual practice without informing patients (this would be considered unethical care), which reduces or eliminates the desired placebo effect. However, by using placebos in research, during which they don't have to inform the participant, sc...
Increasingly, systematic reviews of healthcare interventions include observational studies when RCT evidence is considered inadequate; trials may be considered infeasible or unethical, do not report long-term or less common serious outcomes (particularly harms), or do not reflect use in real-world ...