Characterization of Adrenergic Receptors, with Examples from some Sympathetically Innervated Structuresdoi:10.1111/j.1600-0773.1979.tb03227.xChrister OwmanBlackwell Publishing Ltd
Thus, the effects of these drugs may vary depending on the external milieu. Receptors may be up- or downregulated by disease or by the drug itself. For example, adrenergic blockers upregulate ß-receptor density during chronic therapy. While this effect does not usually result in resistance ...
Read the following passage and then do the exercises (multiple choice) given below. PRINCIPLES OF PHARMACODYNAMICS Once a drug accesses a molecular site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceiv...
They are medications, known as beta-adrenergic blocking agents, which are taken to reduce blood pressure. In short, a beta blocker hinders the effects of epinephrine (also known as adrenaline) by binding to beta receptors on nerves, and beta blockers slow the heart beat down and cause it to...
At the surface of its target cells (muscle cells, and to a lesser extent, liver cells) it binds to a receptor called the β-adrenergic receptor. The β-adrenergic receptor spans the plasma membrane. The intracellular portion of the receptor is bound to a member of the G-protein class of...
Angiotensin II activates proximal Na+-Cl– reabsorption, as do adrenergic receptors under the influence of renal sympathetic innervation; locally generated dopamine, in contrast, has a natriuretic effect. Aldosterone primarily activates Na+-Cl– reabsorption within the aldosterone-sensitive distal nephron....
Variant(s): neurone (British) Synonym(s): nerve cell Related term(s): Mauthner neuron Golgi neuron Relay neuron Nanc neuron Nonadrenergic noncholinergic neuron Intercalary neuron Non-myelinated neuron Unmyelinated neuron Myelinated neuron Multipolar neuron Magnocellular neuronLast...
G-protein coupled receptorsShape complementarity, electrostatic and hydrophobic matching, were used to model drugs and receptors. From known experimental data on alpha1A/alpha2A-adrenergic ligands and alpha1A/alpha2A-adrenoceptors, a model for the ligand binding sites, based on the structure of ...
Receptors, AdrenergicAnalysis of VarianceProtein BindingAtrial natriuretic peptide (ANP) lowers arterial blood pressure (ABP) chronically, in association with vasodilation of the resistance vasculature. The mechanism mediating the chronic relaxant effect of ANP is...