Keywords: BRAF mutation, molecular diagnosis, target therapy Introduction BRAF is a proto-oncogene that has been found to be mutated in a wide range of tumors, including colorectal cancer, malignant melanoma, papillary thyroid carcinoma, and less frequently lung adenocarcinoma.1–8 Cancer metastas...
PROLONGED EXPRESSION OF THE c-kit RECEPTOR IN GERM CELLS OF INTERSEX FETAL TESTES Stem cell factor (SCF) and its receptor Kit encoded by the c-kit proto-oncogene are crucial for the development and migration of primordial germ cells in r... EWA,RAJPERT-DE,MEYTS,... - 《Journal of Pat...
Some members of the Ets family, Ets-1 and Ets-2, cooperate in transcription with the AP-1 transcription factor, the product of the proto-oncogene families, fos and jun , while others, Elk-1 and SAP-1, form ternary complexes with the serum response factor. Some ets gene family members ...
关键词: Chick Embryo Ectoderm Neural Crest Animals Bone Morphogenetic Proteins Proto-Oncogene Proteins Culture Media, Conditioned Culture Techniques Embryonic Induction Signal Transduction DOI: 10.1126/science.1075454 被引量: 1 年份: 2006 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 ProQuest...
The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ ...
Keywords: BRAF mutation, molecular diagnosis, target therapy Introduction BRAF is a proto-oncogene that has been found to be mutated in a wide range of tumors, including colorectal cancer, malignant melanoma, papillary thyroid carcinoma, and less frequently lung adenocarcinoma.1–8 Cancer metastas...
The disease is driven by mutations in proto-oncogenes such asand, while immune-mediated mechanisms contribute ... F Pegoraro,M Papo,V Maniscalco,... - 《Leukemia》 被引量: 0发表: 2020年 AB1002IMMUNOGLOBULIN G4 RELATED DISEASE IN A 10 YEAR-OLD GIRL WITH MULTISYSTEM INVOLVEMENT Background ...
New therapeutic methods may impact the genome level of carcinogenesis. There are many studies aimed at blocking transformed protooncogenes or restore the activity of tumor suppressor genes. Dealing with the process of cancer cells hypoxia and understanding the role of hypoxia inducible factor (HIF) ...