From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase. Cell Mol. Life Sci. 67, 1049-1064. doi: 10.1007/s00018-009-0229-6Hinz, U. & UniProt, C. From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase. Cellular...
Which of the following is NOT a way in which amino acid structure and sequence might affect the properties of a protein? a. Amino acid side chains form peptide bonds with each other, causing the molecule to twist into a...
Beginning in 1982, an education campaign sponsored by a pharmaceuticalcompany was launched to create public awareness of osteoporosis as an important women's health issue. Having found these potentially good protein sequences, the pharmaceuticalcompany is ready to work on them and to hopefully patent...
Barrett's oesophagus: Mucin composition, neuroendocrine cells, p53 protein, cellular proliferation and differentiation There is strong association of Barrett's oesophagus (BO) with adenocarcinoma. The sequence of events preceding malignancy appears to be reflux oesophagitis - ulceration - BO - dysplasia...
starting with the number of nucleotide and protein sequences, but also data from proteomic and transcriptomic studies. Likewise, the number of protein 3D-structures that are deposited at wwPDB (http://www.wwpdb.org/) and integrated via its sites at RCSB PDB, PDBe (formerly MSD), PDBj, and...
A different type of clock is used, a Molecular Clock. Instead of measuring seconds, minutes, and hours, the molecular clock measures the constant rate of change in an organism's genome (DNA or protein sequences of a specific gene) over time. This constant rate of change occurs randomly amo...
Microsequencing of protein electrotransferred onto immobilizing matrices from polyacrylamide gel electrophoresis; application ofinsolubleprotein. How wereinsolubleparticles transported by blood to cells in the first place? Similarly, he dismissed the measurement of heat as aninsolubleproblem. ...
Functional information in SWISS-PROT: the basis for large-scale characterisation of protein sequences. With the rapid growth of sequence databases, there is an increasing need for reliable functional characterisation and annotation of newly predicted protein... Apweiler - 《Briefings in Bioinformatics》...
Protein-tyrosine-phosphatases (PTP-ases), in concert with protein tyrosine kinases, control various biological activities such as cell growth and differentiation. In rodents, around 40 PTP-ases have been described. Functional orthologue for each of these PTP-ases have been identified in human, except...
Insulin is the protein that regulates blood sugar, a lack of insulin, or of sufficient insulin, is what makes a person diabetic, resulting in uncontrolled levels of blood glucose. Often diet can be used to alleviate some of the effects of this lack of insulin, though often medi...