Dose-Response Relationship, DrugKineticsReceptors, DrugExperiments are described both to illustrate techniques of empirical analysis of dose-response curves and to determine whether effects on vagal action might contribute to positive chronotropic effects seen clinically with gallamine and pancuronium. From ...
Problems in Dose Response and Risk Assessment : The Example of Asbestos. In: Castellani, A. (eds) Epidemiology and Quantitation of Environmental Risk in Humans from Radiation and Other Agents. NATO ASI Series, vol 96. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9445-1_11 ...
Conclusion There is a lack of a clear dose-response relationship between body mass index (BMI) and low back pain. Further, studies on the relationship between obesity and related lumbar osteoarthritis, knee pain, and disc herniation are also problematic.There is little doubt that future studies ...
In cases where no official international guidelines have been established, a cut-off point can be used based on the scientific evidence and knowledge accumulated on the dose-response relationship (e.g. heat exposure in cities). In terms of health outcomes, a key source of information throughout...
It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression of metabolic disorders has become evident. In
[37]. Although more recent studies are available on the relationship between calcium intake and osteoporotic frac- ture, this study mentioned a dose–response relationship. In another meta-analysis, it was found that a supplement of 500 to 1,200 mg calcium would reduce the risk of hip ...
The kidneys get rid of waste and extra fluid in the body by filtering the blood to produce urine. They also keep electrolyte levels balanced and make hormones that influence blood pressure, bone strength and the production of red blood cells. When something interferes with the kidneys, they can...
A dose-response relationship was found between BW and ME. High ME may serve as a buffer for children with a biological risk for developmental delays. A clinically important finding was that children born with very low BW to mothers with low ME were at a high level of individual risk for ...
affects different host functions [45]. A substantial portion of gut physiology, including the modulation of gut motility, intestinal barrier homeostasis, nutrient absorption, and fat distribution, is believed to be influenced by the mutualistic relationship between intestinal microorganisms and their human...
Biologic therapy involving anti-tumor necrosis factor-α (anti-TNFα) agents has fundamentally changed the management of patients with immune-mediated inflammatory diseases, including rheumatoid arthritis, thus benefiting many patients. Nevertheless, the inability of some patients to achieve low disease act...