Specifically, we used circular dichroism, UV spectroscopy and fluorescence spectroscopy to characterize the conformation, stability and binding affinity for kanamycin-B and other aminoglycoside antibiotics to these RNA hairpins. Our results show that the mutations affect the conformation of the decoding ...
More intriguing is the presence of genes resistant against multiple antibiotics and the broad range of beta-lactams (cephalosporins, cephamycin, carbapenem, penam, penem, monobactam). Beta-lactams are the last choice of drugs used to treat chronic infections [55]. Multiple drug resistance is ...