Although the problems inherent in the prospective design are unavoidable they are not, in the study described, a barrier to scientific and policy value. That seems also likely in Britain's two later born national birth cohort studies that have continued into adulthood....
The method is demonstrated in connection with a study of lung cancer among metal-workers exposed to oil mist. As exposure to oil mist is uncommon and lung cancer is common, the cohort study is the method of choice. Estimation of exposure, problems of selection, calculation of person-years et...
In a traditional clinical trial, the design is fixed in advance, the study is carried out, and the data analysed after completion [1]. In contrast, adaptive designs pre-plan possible modifications on the basis of the data accumulating over the course of the trial as part of the trial proto...
Study design: Patients identified from dispensed prescriptions issued by general practitioners for Intrinsa between March 2007 and August 2010. Postal questionnaires were sent to general practitioners six months following the date of the first prescription for Intrinsa for each patient, requesting ...
to the need to adapt to the continuously evolving infection rates, leaving limited opportunities for evaluation and adjustment of study design. Summarising the most important lessons learned from this period, we recommend focusing on three core factors in the design of questionnaires during a pandemic...
A systematic review is a type of review that uses repeatable methods to find, select, and synthesize the available evidence.
pharmacoepidemiological analyses of observational health care data using a running example of a hypothetical COVID-19 study. A detailed supplement presents a practical how-to guide for following each rule. When carefully designed and properly executed, a retrosp...
a major concern. To address such concerns, next-generation anti-TNFα agents that differ from the immunoglobulin G-format anti-TNFα agents that have been used to date are being developed using antibody-engineering technology. Their unique design employing novel molecular characteristics affords ...
After harmonisation of spatial resolution, using a full factorial design matrix to accommodate global differences, and leaving out controls older than 60 years, we achieved detection rates of up to 71% for both databases combined. Detection rates were similar across the three scanner types used for...
counterintuitive findings may have wide-reaching implications, a careful setup and execution of RI-CLPM analyses, including the consideration of within time point associations in the context of the study’s design and the used measures, is vital to ensure the robustness and validity of the result....