Background Determination of the plasma concentrations of arginine and other amino acids is important for understanding pathophysiology, immunopathology and nutritional supplementation in human disease. Delays in processing of blood samples cause a change in amino acid concentrations, but this has not been ...
Currently, many traditional models used to study bacterial infections fail to precisely replicate the in vivo bacterial environment. These models often fail to incorporate fluid flow, bio-mechanical cues, intercellular interactions, host-bacteria interactions, and even the simple inclusion of relevant ...
We hypothesize that explanted intestinal segments from rats will demonstrate reduced susceptibility to ischemic injury when perfused with l-arginine.Methods45 small intestinal segments were harvested from male Sprague-Dawley rats and connected to an ex vivo intestinal perfusion device. Ischemic damage was ...
Supplemental L-Arginine During Cardioplegic Arrest and Reperfusion Avoids Regional Postischemic Injury. J. Thorac. Cardiovasc. Surg. 110(2):302-14 (1995). Matsuno et al. The Effect of Machine Perfusion Preservation Versus Cold Storage on the Function of Kidneys from Non-Heart-Beating Donors. ...
Protein transport in human cells mediated by covalently and noncovalently conjugated arginine-rich intracellular delivery peptides. Peptides. 2009;30(9):1669–78. https://doi.org/10.1016/j.peptides.2009.06.006. Article CAS PubMed Google Scholar van den Berg A, Dowdy SF. Protein transduction ...
Ischemic vessels were incubated for 10 min with 1 mM DAF-2DA dissolved in HBS containing 1 mM L- arginine. Images were taken under 4X objective of the microscope. Images are the representative of 3 individual experiments. (B) The green luminosity of the fluorescent images...
inhibits the protein from being degraded by an enzyme in vivo during such delivering process, and promotes the introduction of the bioactive material into a cell or the selective introduction of the bioactive material into a specific cell by binding an antibody, a ligand, a cell-permeable peptide...
Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model: the Role of l-arginine and Nutraceutical NanoparticlesIntroduction: Diarrhea is still a leading cause of death in children and the elderly worldwide, especially during antibiotic therapy...
In the vascular endothelium, NO, a vasodilator produced from arginine by NO synthase, migrates to the vascular mesothelium by auto-diffusion, activating guanylate cyclase, increasing the cyclic guanosine monophosphate concentration, activating protein kinase G, and decreasing the intracellular Ca ion ...
Their structure consists of short positively charged peptides (seven amino acid residues at most), mainly due to lysine (K) or arginine (R) residues, linked to a fatty acid chain [14,15,16,17]. As a result, these compounds are amphiphilic and easily react with the negatively charged ...