EWSR1(E7)-CREM(E6) FusionEnquiry Product Description Product database CBP20138R FormatRNA DescriptionN/A Technical Data Left GeneEWSR1 Left Breakpointchr22:29683123:+ Right GeneCREM Right Breakpointchr10:35495823:+ Cosmic IDN/A ...
TheEWSR1::CREMfusion gene, caused by a chromosomal translocation t(10;22)(p11;q12), has been discovered in divergent malignancies, ranging from low-grade to highly malignant cancers. The translocation gives rise to a chimeric protein, EWSR1::CREM. The molecular mechanisms behind the oncogenic ...
该病例至本院行病理会诊后,二代测序结果提示瘤组织具有EWSR1-CREM基因融合,最后诊断为"EWSR1-CREM基因融合的恶性上皮样肿瘤并腹腔多发转移"。 治疗方法左侧附件切除术,盆、腹腔肿块多发(转移)病变切除术,化疗。 临床转归手术5个月MRI复查发现肝门区"淋巴结"肿大,无其他特殊。 适合阅读人群病理科;肿瘤科;儿童肿瘤科...
染色体易位混杂的一个显著例子是EWSR1或FUS与编码CREB转录因子家族(ATF1、CREB1和CREM)的基因之间的融合,这种融合驱动了跨间充质、神经外胚层和上皮谱系的各种肿瘤类型的发病机制。 ②研究了一组13例以前未分类的恶性上皮样肿瘤,这些肿瘤通常表现出上皮免疫表型和明显的腹膜腔好发性,由EWSR1/FUS-CREB融合定义。 ③...
Hyalinizing clear cell carcinoma of the lung with EWSR1::CREM fusion Sir, Hyalinizing clear cell carcinoma is a low-grade carcinoma, most commonly found in the accessory salivary glands. This tumour is a new entity, describe... V Grosjean,P Fournel,T Picot,... - 《Histopathology Official...
Fusion‐driven cutaneous and superficial mesenchymal and adnexal tumors—A clinicopathologic and molecular study of 15 cases, including a novel case of ACT... EWSR1 (6) fused to ERG (1), FLI1 (1), CREB1 (2), CREM (1), PBX3 (1), followed by PLAG1 (4) with LIFR (2), TRPS1 (...
fusion genepulmonary tumorEWSR1-CREM gene fusions were recently discovered in several mesenchymal and epithelial tumors, including myxoid mesenchymal tumors of the central nervous system, rare cases of soft tissue clear cell sarcoma and angiomatoid fibrous histiocytoma, and hyalinizing clear cell ...
EWSR1(E7)-CREM(E6) Fusion询价 产品描述 产品数据库 CBP20138R Format RNA Description N/A Technical Data Left Gene EWSR1 Left Breakpoint chr22:29683123:+ Right Gene CREM Right Breakpoint chr10:35495823:+ Cosmic ID N/A Buffer RNase-free H2O Product...
EWSR1:CREM fusion has been identified in rare cases of angiomatoid fibrous histiocytoma, clear cell sarcoma, hyalinizing clear cell carcinoma of the head and neck, and intracranial myxoid mesenchymal tumor. Our study represents the largest to date and seeks to expand and further define the ...
These tumours are characterized at the molecular level by the presence of an EWSR1::ATF1 fusion transcript. However, in the salivary glands the presence of an EWSR1::CREM transcript is reported in rare cases. In the lung, the presence of an EWSR::CREM transcript is less well documented,...