Elucidation of EWS/ETS target gene networks in the context of other signaling pathways will hopefully lead to biology based therapeutic strategies for EFT. Oncogene (2001) 20, 5747-5754.NatureOncogeneArvand A,Denny CT.Biology of EWS/ETS fusions in Ewing’s family tumors. Oncegene . 2001...
of E S /pP N ET kno wn to have t he EWS - Ets fus io n p ro duct a s p rev io us ly de te rm ine d by s e q ue nce ayalysis were used as pos itive controls. T ype II E W S - Flil pos itive co nt ro 1 wa s kindly prov ided bv D r. Ma...
Tumor-associated chromosomal translocations lead to the formation of chimeric fusions between the EWS gene and one of five different ETS transcription factors in Ewing's family tumors (EFTs). The resultant EWS/ETS proteins promote oncogenesis in a domina
ETS1/EWSR2Human 发布时间:2025/3/5 11:47:29 关注度:508 种 属:Human/Mouse/Rat 标 签:详询 规 格:10ug/50ug/500ug/1mg 缓 冲 液:0.01mol/L的PBS、pH:7.2、0.2%Procline-300。 表达宿主:E.coli/Cells 内毒素:经LAL检测验证,小于0.1ng/ul(0.1EU/ug) 纯化方法:亲和纯化。 应用范围:用于细胞培...
Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. Cancer Biol Ther. 2005;4:449-55.Irifune H, Nishimori H, Watanabe G, et al. Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing's family tumors. Cancer Biol Ther 2005; 4:...
The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene. 2002;21:8302-9.Nishimori H, et al. The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene. 2002;21(...
本期介绍的是西班牙病理专家Machado等人撰写的EWSR1与非ETS基因融合(EWSR1::NFATC2、EWSR1::PATZ1)的肉瘤相关内容。 简介 肉瘤中检测早已明确的致癌基因融合具有重要临床意义,因为其具体临床行为和肿瘤生物学都会受到融合驱动的显著影响。不过...
一种具有EWSR1或FUS基因与非ETS家族基因融合的圆形或梭形细胞肉瘤(WHO) EWSR1-non-ETS 融合肉瘤类型 1.EWSR1-NFATC2融合肉瘤 2.FUS-NFATC2融合肉瘤 3.EWSR1-PATZ1融合肉瘤 临床特点 1. 发病年龄: EWSR1-NFATC2或FUS-NFATC2融合肉瘤年龄12-67岁,男:女为5:1 ...
对于EWSR1/FUS::非ETS家族基因融合的圆细胞肉瘤来说,EWSR1/FUS::NFATC2融合肉瘤可能是最常见、且相关表型了解最为详尽的类型。根据定义,该肿瘤最常见的是存在EWSR1(22q12.2)和NFATC2(20q13.2)的融合,一般是由于不平衡易位及共扩增所...
Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma Buch T, Niggli FK, Schafer BW, Burdach S, Richter GH (2016) Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma......