Ewing sarcoma target genesDespite their clonal origins, tumors eventually develop into complex communities made up of phenotypically different cell subpopulations, according to mounting evidence. Tumor cell-intrinsic programming and signals from geographically and temporally changing microenvironments...
Interestingly, ALS-associated mutant EWSR1 proteins show increased proclivity to form aggregated proteins than WT EWSR1, which suggests the possibility of these mutations causing accelerated aggregation in the affected motor neurons. Furthermore, overexpression of mutant EWSR1 in Drosophila causes ...
22 If Drosha levels are elevated in the cell, more mature form of pre-miRNAs will be produced and, consequently, more mature form of miRNAs will be processed in a cell-specific manner. In this paradigm, our study indicates that Drosha is directly regulated by EWS as an upstream target of...
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doi:10.3390/cancers15245750Benjamin B. OzenbergerLi LiEmily R. WilsonAlexander J. LazarJared J. BarrottKevin B. JonesCancers