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Ewing’s sarcoma is a rare type of cancerous tumor that grows in the bones or the soft tissue around the bones, such as cartilage. It is most common in children and young adults, but anyone can have it. Ewing’s sarcoma affects about 200 children and young adults every year in the Un...
The Ewing sarcoma/primitive neuroectodermal tumor (EWS) is a malignant small round cell tumor of the bone and soft tissues, and ranks second in frequency among primary bone tumors in children and adolescents. EWS is aggressive, and is associated with the most unfavorable prognosis of all primary...
Ewing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone and soft tissue. Suffering from intractable or recurrent diseases, the patients’ therapy options are very limited. It is extremely urgent to identify novel potential
Bozzi F, Tamborini E, Negri T, Pastore E, Ferrari A, Luksch R, et al . Evidence for activation of KIT, PDGFRalpha, and PDGFRbeta receptors in the Ewing sarcoma family of tumors. Cancer. 2007;109:1638–45.Bozzi F, Tamborini E, Negri T, Pastore E, Ferrari A, Luksch R, et al. ...
Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, and surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse and die of the disease due to chemoresistance. Here, using phospho-profiling, we find Ewing sarcoma cells treated with ...
Ewing sarcoma is a highly aggressive malignant bone tumor occurring preferentially in children and young adults. At present, only clinical features, such as patient age, presence of clinically evident metastases at diagnosis, and poor response to neoadjuvant chemotherapy, are widely accepted as prognosti...
et al. Biological indicators of prognosis in Ewing's sarcoma: an emerging role for lectin galactoside-binding soluble 3 binding protein (LGALS3BP). Int. J. Cancer 126, 41–52 (2010). Article CAS Google Scholar Cermak, V. et al. The transcription factor EGR1 regulates metastatic potential...
Ewing sarcoma Cancer stem cells Let-7a STAT3 Lin28 1. Introduction Ewing sarcoma is a cancer of the soft tissue and bone. Among them, the Ewing sarcoma of bone is a kind of greatly malignant primary bone tumor, which is common in children and adolescents, which progresses rapidly [1]. Fo...
Cancer Cell International 2013, 13:21 http://www.cancerci.com/content/13/1/21 PRIMARY RESEARCH Open Access miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor Keiichiro Iida1, Jun-ichi Fukushi1*, Yoshihiro Matsumoto1, Yoshinao Oda2, Yusuke Takahashi2, Toshifumi ...