Antibiotic resistance may be regarded as the paradoxical consequence of the success of antibiotic therapy. Bacteria develop antibiotic resistance in two main ways: horizontal gene transfer and mutation in different chromosomal loci. The Mycobaterium tuberculosis species has to acquire antibiotic resistance ...
Evolution of antibiotic resistance. Trends in Ecology & Evolution 12, 482.Baquero F, Blazquez J (1997) Evolution of antibiotic resistance. Trends Ecol ... F Baquero,J Blázquez - 《Trends in Ecology & Evolution》 被引量: 371发表: 1997年 Evolution of antibiotic resistance Trends in Ecology &...
The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on ...
The evolution of bacterial pathogens towards antibiotic resistance is not just a relevant problem for human health, but a fascinating example of evolution that can be studied in real time as well. Although most antibiotics are natural compounds produced by environmental microbiota, exposure of ...
Infections, especially peritoneal dialysis-related peritonitis, are unavoidable because of lapses in technique and the slow worsening of systemic and peritoneal defense associated with aging and dialysis. The selective pressure inherent in the use of antibiotics shapes the pattern of antibiotic resistance ...
should be conducted upon communities in addition to single-cell cultures because resistance is determined by the interactions taking place within that specific community; (2) This should be combined with analyses exploring the consequences of antibiotic treatments on community structure and functioning, wh...
relevant levels of resistance. Subsequent evolution occurred by mutations in a regulatory RNA that increased the plasmid copy number, resulting in marginal gains in ceftazidime resistance. These results uncover a role for multicopy plasmids as catalysts for the evolution of antibiotic resistance in bacter...
Antibiotics have always been considered one of the wonder discoveries of the 20th century. This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities, and the environment concomitant with their use. The extraordinary genetic capacities of microbes have benefitted...
, were included.Bacteroides and Clostridium difficile resistance to moxifloxacin increased globally.Bacteroides, Prevotella, C.difficile and anaerobic cocci showed resistance changes.Decrease in antibiotic resistance in anaerobes was also found.Five main factors were associated with evolution of the resistance...
Gene-drug interactions and the evolution of antibiotic resistance. The evolution of antibiotic resistance is shaped by interactions between genes, the chemical environment, and an antibiotic's mechanism of action. This thesis explores these interactions with experiments, theory, and analysis, seeking a ...