the immunogenicity of linear peptides is better understood43. We observed that our affinity-matured variants have no significant increase (one-sided binomialP > 0.05) in the number of computationally predicted peptide binders to both human leukocyte antigen (HLA) class I and class II (exactP...
The ecological niche can be thought of as a volume in multidimensional space, where each dimension describes an abiotic condition or biotic resource required by a species. The shape, size, and evolution of this volume strongly determine interactions amon
We identified a new cryptochrome class, cryptochrome DASH, and characterized it with respect to evolution, structure, and function. Major findings include the following: (1) cryptochromes likely evolved before the separation of prokaryotes and eukaryotes, (2) crystal structures of cryptochrome DASH and...
Class I cytokine receptor complexes have traditionally been divided into families based on the use of common signal transducing chains within a receptor complex [3]. However, more recently researchers have placed the individual receptor chains into five groups. This is based on sequence and structural...
The third class was described as class I, or members of the subtilisin family [4]. Members of this family in fungi usually have inserts in the catalytic domain, and long carboxyl-terminal extensions, which are both characteristic of a family described as pyrolysins [3]. However, the pyrolys...
After undergoing ten-fold cross-validation, the DeepGH models exhibited a predictive accuracy of 96.73%. The utilization of gradient-weighted class activation mapping (Grad-CAM) was used to aid us in comprehending the classification features, which in turn facilitated the creation of enzyme mutants....
of angiosperm morphogenesis and ecology. The term is applied at all levels of plant biology, from processes at the biome-wide scale that define the season of autumn in temperate climates [1,2] through to the cellular dimension in the terminal development of individual tissues and organs [3,4...
1 orthologs of CYPs (IPR001128) were found betweenF. fuscaandA. pisum,F. fuscaandZ. termopsis, andF. fuscaandD. melanogaster,respectively. CYPs can be taxonomically broken down into two classes (B-class and E-class), with E-class being found primarily within eukaryotes and itself ...
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ligninolytic peroxidases (class II POD) implicated in white rot26. This dataset presents an opportunity to carry out a broader analysis of the evolution of saprotrophic capabilities than that we previously attempted in our large-scale comparative analysis of Agaricomycetidae12. In the present ...