Fish Transgenic zebrafish Aquarium Embryonically 0.1, 1, 10, 100, 1,000 μg/L 48, 55 h after fertilization BPA1 and 10 increased hatching rate (41) Rat Long Evans Oral gavage + lactation GD7–PND18 2, 20, 200 μg/kg/d After birth and over 4 mo No effect on litter size (42) ...
During subsequent stages of pre-implantation development, Xist RNA spreads from its site of synthesis to eventually coat most of the Xp4,5,9, concomitant with transcriptional silencing of Xp-linked genes4,10,11. Imprinted XCI of the Xp is then maintained in extra-embryonic tissues of the ...
Hep3B (human HCC cell line), WRL68 (human normal liver cell line) and HEK293 (human embryonic kidney cell line expressing the E1A region of human adenovirus type 5) were from American Type Culture Collection (ATCC, Manassas, VA, USA), while HuH7 (human HCC cell line) was from JCRB G...
Introduction The Hedgehog pathway (HhP) plays a fundamental role in embryonic development, tissue patterning, and wound healing [1]. Aberrant functioning of this pathway is related to several congenital abnormalities and the development of cancer in several organs [2,3]. The idea that alterations ...