The frequent occurrence of elevated liver enzymes in otherwise healthy diabetics confounds evaluation of drug-induced hepatotoxicity in clinical trials involving diabetic patients. In a recent single-dose tolerance study of an aldose-reductase inhibitor, we found abnormal liver enzyme tests occurring in ...
Because elevated liver enzymes are found in 1% to 4% of asymptomatic persons, extensive evaluation of all abnormal tests would expose many patients to undue risks and medical costs. On the other hand, not evaluating minor elevations of liver enzymes could result in missing the early diagnosis of...
Of the seven patients in whom treatment was stopped, pathological laboratory values normalized in four (57.1%) with 6-TG discontinuation after a median dura- tion of 25 weeks (range 4–40), but in the remaining three patients elevated liver enzymes failed to recover by the end of the ...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are administered as single agents. For elevated liver enzymes, inter...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are administered as single agents. For elevated liver enzymes, interru...
6. The presence of multiple abnormal test results makes significant liver disease more likely. 7. Aminotransferase, alkaline phosphatase, and GGT levels can be elevated from causes other than liver disease. 8. Persisting abnormalities of aminotransferases or enzymes of cholestasis should be further eva...
It was found that the level of CysC was positively correlated with microinflammatory indexes such as interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and C reactive protein (CRP) It was also suggested that the elevated level of CysC activated mononuclear macrophage system, ...
and prostate) and sex hormone-independent (kidney and urothelium) tissues [2]. AKR1C3 is overexpressed in various solid tumors and hematologic malignancies, with strikingly elevated intensity in certain tumors (e.g., breast, prostate, endometrium, gastrointestinal tract, pancreas, liver, and kidney...
For elevated liver enzymes, interrupt KEYTRUDA and axitinib, and consider administering corticosteroids as needed. With the combination of KEYTRUDA and axitinib, Grades 3 and 4 increased alanine aminotransferase (AL...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are administered as single agents. For elevated liver enzymes, interrupt KEYTRUDA ...