The frequent occurrence of elevated liver enzymes in otherwise healthy diabetics confounds evaluation of drug-induced hepatotoxicity in clinical trials involving diabetic patients. In a recent single-dose tolerance study of an aldose-reductase inhibitor, we found abnormal liver enzyme tests occurring in ...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are administered as single agents. For elevated liver enzymes, interrup...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are administered as single agents. For elevated liver enzymes, interr...
Monitor liver enzymes before initiation of and periodically throughout treatment. Consider more frequent monitoring of liver enzymes than when the drugs are administered as single agents. For elevated liver enzymes, interrupt CABOMETYX and nivolumab ...
Monitor patients closely for symptoms and signs that may be clinical manifestations of underlying immune-mediated adverse reactions. Early identification and management are essential to ensure safe use of anti–PD-1/PD-L1 treatments. Evaluate liver enzymes, creatinine, and thyroid function at baseline ...
Liver Biochemical AbnormalitiesElevated serum transaminases were reported in clinical trials with BIMZELX. Test liver enzymes, alkaline phosphatase, and bilirubin at baseline, periodically during treatment with BIMZELX, and according to routine patient management. If treatment-related increase...
KEYTRUDA in combination with axitinib can cause hepatic toxicity. Monitor liver enzymes before initiation of and periodically throughout treatment. Consider monitoring more frequently as compared to when the drugs are ...
Elevated TGF-β levels in the tumor microenvironment have an adverse effect on antitumor immunity and inhibit host immune surveillance [200]. This suppressive cytokine [200,201] abrogates the secretion of critical Th1 cytokines, such as IFN-γ, and impairs NK cell cytolytic activity and ...
The prevalence of degenerative diseases has been escalating due to the mounting presence of oxidative stress conditions, characterized by elevated levels of reactive oxygen species (ROS). Oxidative stress triggers genetic alterations, structural modifications, and the progression of various degenerative disor...
For elevated liver enzymes, interrupt KEYTRUDA and axitinib, and consider administering corticosteroids as needed. With the combination of KEYTRUDA and axitinib, Grades 3 and 4 increased alanine aminotransferase...