These variations combined with the need to obtain narrow ranges in serum levels necessitated measuring serum concentrations and individually calculating each patient's dose and dosing interval. Optimal peak and trough serum concentrations were reliably and rapidly achieved by means of this method. ...
The results of PK study showed that the C(max) and AUC(0-∞) of levofloxacin were 14·94 μg/mL and 80·14 μg h/mL following single-dose infusion of levofloxacin. The half-life and average cumulative urine excretion ratio within 72 h post-dosing were 7·75 h and 86·95%, ...
Article: Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal
Adult female ferrets were found to absorb 85.4% of a single dietary dose of the polychlorinated biphenyl (PCB) mixture Aroclor 1254. Excretion in the days immediately following dosing yielded the greatest quantity of PCBs eliminated in a given time period. In general, urinary excretion represented ...
Chapter 11960 provides bibliographic information on scholary research in the basic and applied life, earth and health sciences.