et al. The Eukaryotic Linear Motif Resource (ELM): Regulatory Sites in Proteins. Nat Prec (2009). https://doi.org/10.1038/npre.2009.3152.1 Download citation Received23 April 2009 Accepted23 April 2009 Published23 April 2009 DOIhttps://doi.org/10.1038/npre.2009.3152.1 Share this article ...
The Eukaryotic Linear Motif resource (ELM) was established over 15 years ago as a repository to store and catalogue the scientific discoveries of motifs. Each motif in the database is annotated and curated manually, based on the experimental evidence gathered from publications. The entries ...
Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, regularly updated and well-organised repository of manually curated, experimental...
For a similar reason, using the sole regular expression to detect linear motifs matches in sequences has almost no predictive power because they are both statistically insignificant and prone to massive over-prediction. The Eukaryotic Linear Motif resource (ELM - "...
Gould CM, Diella F, Via A, Puntervoll P, Gemünd C, Chabanis-Davidson S, Michael S, Sayadi A, Bryne JC, Chica C,et al.: ELM: The status of the 2010 Eukaryotic Linear Motif Resource.Nucleic Acid Research2010. 10.1093/nar/gkp1016 ...
REAGENT or RESOURCESOURCEIDENTIFIER Bacterial and Virus Strains E. cloni 10G Chemically Competent Cells Lucigen Cat#60107-2 Escherichia coli MG1655 Blattner et al., 1997 ATCC: 700926 Chemicals, Peptides, and Recombinant Proteins Enterobactin Sigma Aldrich Cat#E3910 Chromeazurol S MP Biomedicals, LLC...
8) are confounded by high number of protein- protein interactions or higher density of linear motifs or PTM sites associated with HRPs, we classified yeast proteins into three bins of low, medium and high using tertile cut-offs for each of the features (panel b). Linear motif residue ...
We created an initial degron resource by generating a large set of native and non-native degrons, representing more than a 10-fold increase in the field (Figure 1). The method employed to construct the library was designed to achieve two goals: (1) to enlarge sequence complexity and (2)...
(Fig. 2b)50. Replication origins in human cells associate with a G quadruplex (G4)-forming consensus motif 51; thus there is an intriguing coincidence between the location and function of the G-rich RNA/ssDNA-binding domain. The EOS-homologous motif and the G-rich RNA/ssDNA-binding ...
REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Monoclonal ANTI-FLAG M2 antibody produced in mouse Sigma-Aldrich F1804RRID:AB_262044 RDye 800CW Goat anti-Mouse IgG (H + L) VWR 926-32210RRID:AB_621842 Anti-FLAG M2 Magnetic Beads Sigma-Aldrich M8823RRID:AB_2637089 Bacterial and Virus Strains E....