Draw a labelled diagram depicting eukaryotic protein-coding gene containing three exons. Indicate the following on your diagram: promoter, transcription start site(+1),RNA coding region, exons, introns, terminator,5'UTR and3'UTR. Pre-mRNA m...
Schema of a simple phylogenetic profiling pipeline. A) genes (dots) are grouped using a biologically relevant criterion (e.g. orthology) in a diverse set of genomes (rectangles). B) a matrix is constructed with rows corresponding to groups and columns corresponding to genomes. Each cell in th...
Molecular dynamics simulations suggest a translocation pathway from the binding site to the inside of the cell (Fig. 5a and Supplementary Figs 7 and 8). Given the resolution of the crystal structure, these data should be treated with caution; however, the results are consistent with the ...
Because of its essential role in eukaryotic cells, interfering with host-cell proteins phosphorylation is a common strategy used by bacterial pathogens to hijack cell functions8. A growing number of bacterial effectors targeting phosphorylation pathways have been shown to play a role in infection (...
However, prophages have also been described as molecular time bombs [5] that, either spontaneously or in response to specific environmental conditions, kill their carriers through cell lysis and switch back to the lytic cycle [3, 5]. While bacteria are in constant coevolutionary interaction with ...
The structure is drawn as a ribbon diagram, coloured blue to light green from the N to the C terminus. The six blades of the propeller are labelled WD1 to WD6, from the N to C end. The helical domain has been omitted for clarity. b, Two views of the Ctf4(CTD) protomer, ...
(homing). In a diploid cell heterozygous for the intein, cleavage of the empty allele by the homing endonuclease will be followed by DNA repair performed by the host repair machinery, using the occupied allele as a template [8]. This will result in the cell becoming homozygous for the ...
EIF4H-L, but not EIF4H-S, is critical for LUAD cell proliferation, survival and tumourigenesis. Interpretation Our study demonstrates a new molecular mechanism underlying RBM10 suppressive functions in lung cancer and the therapeutic value of RBM10-regulated AS events, providing important ...
This may be an adaptation arising from the localization of bacterial A2Ms to the cell wall in contrast to eukaryotic A2M/complement/TEP proteins, which are found in the circulatory system. The structural alignment of the available structures from the A2M/complement/TEP superfamily also provides ...