Operons are a hallmark of bacterial genomes, where they allow concerted expression of multiple functionally related genes as single polycistronic transcripts. They are rare in eukaryotes, where each gene usually drives expression of its own independent messenger RNAs. Here we report the horizontal ...
Eukaryotic acquisition of a bacterial operon. Cell. 2019;176(6):1356-66.e10. Article CAS PubMed PubMed Central Google Scholar Gonçalves C, Gonçalves P. Multilayered horizontal operon transfers from bacteria reconstruct a thiamine salvage pathway in yeasts. Proc Natl Acad Sci USA. 2019;116...
Several fungi, including Pichia stipitis and Debaryomyces hansenii, possess an alternative pathway of l-rhamnose metabolism, which is different from the known bacterial pathway. Gene cluster related to this hypothetical pathway was identified by bioinformatic analysis using the metabolic enzymes involved ...
The genome of Pseudomonas aeruginosa contains at least three genes encoding eukaryotic-type Ser/Thr protein kinases, one of which, ppkA, has been implicated in P. aeruginosa virulence. Together with the adjacent pppA phosphatase gene, they belong to the
In bacteria, entire thiamine biosynthesis operons can be under TPP riboswitch control (Breaker, 2011). The riboswitch binding interaction is highly specific for the target small molecule and causes a conformational change that results in various forms of gene control without involvement of other (...
The genome of Pseudomonas aeruginosa contains at least three genes encoding eukaryotic-type Ser/Thr protein kinases, one of which, ppkA, has been implicated in P. aeruginosa virulence. Together with the adjacent pppA phosphatase gene, they belong to the
Two-component signaling systems regulate most aspects of a bacterial life, including responses to almost all changes in the environment of a bacterium [5]. Two-component systems regulate global responses to stresses, the switch from free-living to symbiotic or virulent life styles, and the switch...
3. Eukaryization of tRNA Genes: Monocistrony and Control by a Separate RNA Polymerase A substantial fraction (up to 75%) of bacterial and archaeal genomic tRNA sequences reside in polycistronic operons with ribosomal RNA (rRNA)s and other tRNAs and/or other RNA types, all of which are ...