Acute Lymphocytic Leukemia & Other Malignancies Diagnostic Kit The ETV6-NTRK3 Dual Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ETV6 and NTRK3 genes, located on chromosome bands 12p13.2 and 15q25.3, respectively. ETV6 is also known as TEL, THC5 ...
Characterization of a newly identified ETV6–NTRK3 fusion transcript in acute myeloid leukemia. Diagn Pathol. 2011; 6 :19. doi: 10.1186/1746-1596-6-19. [ Cross Ref ]Kralik JM1, Kranewitter W, Boesmueller H, Marschon R, Tschurtschenthaler G, Rumpold H, Wiesinger K, Erdel M, Petzer ...
2012, Leukemia Research Citation Excerpt : Given the fact that ETV6-PDGFRA can transform cells, this suggests that the auto-inhibition induced by the WW-like domain to prevent kinase over-activation is overcome by enforced homodimerization [44,47]. Although the t(12;15)(p13;q25) associated wit...
pediatric leukemiaETV6-NTRK3t(1215) translocationRT-PCRdoi:10.1002/mpo.1222Angela J. AlessandriDepartment of PediatricsStevan R. KnezevichDepartment of PediatricsJoan A. MathersDepartment of PediatricsKirk R. SchultzDepartment of PediatricsPoul H.B. Sorensen...
:圭:坠 山东大学硕士学位论文 融合基因ETV6一NIRK3 在成人白血病和乳腺癌中的表达及意义 研究生 段衍超 导师 郭农建教授 专业 血液内科 中文摘要 目的: (1)通过对2例融合基因ETV6-NTRK3阳性的自血病患者进行临床疗效观察和随 访,初步探讨该融合基因在成人白血病中表达的意义。 (2)研究融合基因翻N岳NⅡlK3在...
in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK...
ETV6–NTRK3, initially described in congenital fibrosarcoma, has been identified in tumors of various lineages, including cellular mesoblastic nephroma, acute myeloid leukemia, breast secretory carcinoma, and secretory analog carcinomas of various sites, most frequently of the salivary glands.1, 9, ...
Here we genetically characterized the acute promyelocytic leukemia (APL) cell line AP-1060 and, by doing so, revealed the presence of a t(12;15)(p13;q25). Subsequently, we evaluated its suitability as a model for this important clinical entity.Chen, SuningNagel, StefanSchneider, BjoernDai, ...
This case report presents a refractory acute myeloid leukemia (AML) patient, accompanied with ETV6::NTRK3, was failed by traditional chemotherapy, then entered long-term remission after hematopoietic stem cell transplantation (HSCT) and maintenance therapy with entrectinib. It was...
Although some gene rearrangements associated with leukemia are rare, study of these infrequent events has defined transcription factors critical for normal differentiation and pathways more generally perturbed in malignancy. Until lately, the contribution of chromosomal rearrangements to epithelial cancers has ...