ETV6::NTRK3 gene fusion in a patient with metastatic lung atypical carcinoid successfully treated with repotrectinib: A case report. Lung Cancer. 2024 Jan;187:107443. doi: 10.1016/j.lungcan.2023.107443. Epub 2023 Dec 15. PMID: 38113652....
首页 / 癌基因 / NTRK3 / ETV6-NTRK3 FUSIONNTRK3(neurotrophic receptor tyrosine kinase 3) 该基因编码神经营养性酪氨酸受体激酶(NTRK)家族的一个成员。这种激酶是一种膜结合受体,通过神经营养素结合,磷酸化自身和MAPK途径的成员。通过这种激酶的信号传导导致细胞分化,并可能在感知身体位置的本体感受神经元的...
AI-Edigene® ETV6(E5)-NTRK3(E15) FusionEnquiry Product Description Product databaseCBP20140R Format RNA Description N/A Technical Data Left Gene ETV6 Left Breakpoint chr12:12022903:+ Right Gene NTRK3 Right Breakpoint chr15:88483984:- Cosmic ID COSF571 Buffer ...
The ETV6-NTRK3 Dual Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human ETV6 and NTRK3 genes, located on chromosome bands 12p13.2 and 15q25.3, respectively. ETV6 is also known as TEL, THC5 or TEL/ABL. NTRK3 is also known as TRKC, GP145-TrkC or...
ETV6/NTRK3 Fusion t(12;15) Probe 15T 7500 ETV6/NTRK3融合基因t(12;15)探针 上述基因常发生于各种肿瘤组织内,导致ETV6(TEL)基因与NTRK3(TRKC)基因融合。其次,急性髓系白血病。中胚叶肾瘤,乳腺,唾液腺分泌癌,直肠癌,甲状腺癌,尤文肉瘤,婴儿纤维肉瘤(infantile fibrosarcoma)等。
ETV6-NTRK3 FUSION NTRK3 基因突变 ETV6-NTRK3 Allele Registry ID:别名: ClinVar ID: 基因突变位点 Ref. Build: GRCh37 Ensembl Version: 75 Chr. Start Stop Ref. s Var. Bases 12 11802788 12022903 Transcript ENST00000396373.4 COORDINATE 2 Chr. Start Stop Transcript 15 88483984 88418230 ENST000...
Cancer CellArticleETV6-NTRK3 Fusion Oncogene InitiatesBreast Cancer from Committed MammaryProgenitors via Activation of AP1 ComplexZhe Li,1,4,5Cristina E. Tognon,6,9Frank J. Godinho,1,3,9Laura Yasaitis,1Hanno Hock,1,4,5,10Jason I. Herschkowitz,7Chris L. Lannon,6Eunah Cho,8Seong-Jin Ki...
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q...
ETV6-NTRK3融合基因研究进展Progress of Researsh in ETV6-NTRK3 Fusion Gene ETV6-NTRK3融合基因是在研究先天性纤维肉瘤具有的染色体重排t(12;15)(p13;q25)时发现的,它编码的蛋白是通过ETV6转录因子的螺旋-环-螺旋结构域与NTRK3的蛋白酪氨酸激酶... 段衍超,郭农建 - 《医学综述》 被引量: 0发表: 2008...
Keywords:Fusiongene;Tyrosinekinase;Diagnosis 近年来国外学者在先天性纤维肉瘤(congenitalfibrosarco— iTla,CFS),先天性中胚层肾瘤(congenitalmesoblasticnephroma, CMN)及其他恶性肿瘤中发现了一种新的染色体移位t(12; 15)(p13;q25),使位于12p13的ETV6(ETSvariantgene6)与位 于15q25的神经营养酪氨酸激酶受体3(neuro...