Members of the large ETS family of transcription factors (TFs) have highly similar DNA-binding domains (DBDs)鈥攜et they have diverse functions and activities in physiology and oncogenesis. Some differences in DNA-binding preferences within this family have been described, but they have not been ...
Macrophage inflammation requires ETS2 ETS2 is an ETS-family transcription factor and proto-oncogene21, but its exact role in human macrophages is unclear, with previous studies using either cell lines or complex mouse models and assessing a limited number of potential targets22,23,24,25,26. This...
3. The Ets transcription factor (TF) family is becoming a regular feature in tumourigenesis, particularly in breast cancer. However, the roles and mechanisms of different Ets TFs are largely unknown. 4. The present minireview discusses the research that identified Ets as a regulator of telomerase...
The glucocorticoid receptor (GR) acts as a ubiquitous cortisol-dependent transcription factor (TF). To identify co-factors, we used protein-fragment complementation assays and found that GR recognizes FLI1 and additional ETS family proteins, TFs relaying proliferation and/or migration signals. Following...
The transcriptional coactivator Yes-associated protein (YAP) plays an important role in organ-size control and tumorigenesis. However, how Yap gene expression is regulated remains unknown. This study shows that the Ets family member GABP binds to the Yap promoter and activates YAP transcription. The...
family 2, subfam 2.79 FBXL13; F-box and leucine-rich repeat prot 2.79 RANBP2L1; RAN-binding protein 2-like 1 is 2.79 BLNK; B-cell linker; Homo sapiens B-cell lin 2.79 KHSRP; KH-type splicing regulatory protein 2.79 KIAA0726; KIAA0726 protein; Homo sapien 2.78 FLJ46266; FLJ46266 protei...
Differential sensitivity to methylated DNA by ETS-family transcription factors is intrinsically encoded in their DNA-binding domains Nucleic Acids Res., 44 (2016), pp. 8671-8681 CrossrefView in ScopusGoogle Scholar [43] S. Hong, D. Wang, J.R. Horton, X. Zhang, S.H. Speck, R.M. Blume...
S5E, F). An involvement of AKT in the induction of Ets-1 in sorafenib resistance has also been shown, which involves kinesin family member 14 (KIF14) [81]. In addition, HGF/c-met axis has been linked with sorafenib resistance [82, 83], and since this axis is also known to induce...
Interestingly, ETS1, but no other members of the ETS family, was specifically required for the migration of RAS/ERK-activated endothelial cells. These observations further indicated that cellular crosstalk between CPCs and the endoderm cell subpopulation may have activated the Ras signaling pathway in...
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