The proposed system in China uses intensity targets instead of an absolute cap on emissions, which has raised some concerns about the ability to reduce emissions. Weng et al. (2018) suggest the use of a carbon price floor to ensure a minimal level of emission reduction. Lin and Jia (2017...
Rhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the majority of the clinically more aggressive fusion-positive rhabdomyosarcoma (FP-RMS). Recent stud
Consistent with this notion, Foxo1 has been shown to bind a conserved site in the Il7r proximal promoter28, which overlaps with the proposed GABPα-binding motif18. Moreover, the transcriptional repressor Gfi-1 has also been implicated in the regulation of Il7r expression37. The functional ...
[57], WP1130 has been proposed as a potential pharmacological approach to target Ets-1 towards degradation [58]. Interestingly, treatment with WP1130 potently sensitized soraR cells towards apoptosis as indicated by increased PARP cleavage (Fig.S5E, F). To validate the role of Ets-1 in so...