3.1. Prenatal EtOH, SSRI and Polydrug Exposures Are Associated with Disruption of 5-HT and DA Pathways We performed a series of RNA array assays, using real-time PCR and ddPCR, to study genes regulating the 5-HT and DA pathways and confirmed mRNA data by protein studies (ELISA, flow cyto...
By contrast, EtOH exposure was also associated with the upregulation of DA receptors DRD3 and DRD4 in the fetal brain, while maternal SSRI and polydrug use was associated with the downregulation of DRD3 in the fetal brain. The data in the human fetal brain also demonstrated an association ...