High- level production of ethylmalonyl-CoA pathway-derived dicarboxylic acids by Methylobacterium extorquens under cobalt-deficient conditions and by poly- hydroxybutyrate negative strains. Appl. Microbiol. Biotechnol., 1-13.Sonntag, F. et al. High-level production of ethylmalonyl-CoA pathway-derived ...
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway reductase (or its gene) can be used as a marker for the presence of the ethylmalonyl-CoA pathway, which functions not only in acetyl-CoA assimilation... TJ Erb,IA Berg,V...
The ethylmalonyl coenzyme A (ethylmalonyl-CoA) pathway is one of the central methylotrophy pathways in Methylobacterium extorquens involved in glyoxylate generation and acetyl-CoA assimilation. Previous studies have elucidated the operation of the ethylmalonyl-CoA pathway in C(1) and C(2) assimilation...
First, the pathway requires ATP and reducing power in the form of NADPH2, which thereby diminishes energy and the electron output of the overall process (Fig. 2). Second, the acetate assimilation pathway shares common elements with the polyhydroxybutyrate biosynthetic route. That is, the initial ...
Assimilatory carbon enters the ethylmalonyl-CoA pathway directly as acetyl-CoA, bypassing pathways for formaldehyde oxidation/assimilation and the regulatory mechanisms controlling them, making ethylamine growth a useful condition to study the regulation of the EMC pathway. Wild-type M. extorquens cells ...
This work provides a complete pathway for methanol assimilation in the model methylotroph M. extorquens AM1 and represents an important step toward the determination of the overall topology of its metabolic network. The operation of the ethylmalonyl-CoA pathway in M. extorquens AM1 has major ...
Bill N, Tomasch J, Riemer A, Muller K, Kleist S, Schmidt- Hohagen K, et al. Fixation of CO2 using the ethylmalonyl-CoA pathway in the photoheterotrophic marine bacterium Dinor- oseobacter shibae. Environ Microbiol. 2017;19:2645-60....
(2S)-Methylsuccinyl-CoA dehy- drogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimila- tion. Mol. Microbiol. 73:992-1008.Erb TJ, Fuchs G, Alber BE. (2009). (2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Mol Microbiol 73...
Metabolite profiling of CoA esters involved in the ethylmalonyl-CoA pathway (EMCP).Patrick KieferMarkus BuchhauptPhilipp ChristenBjörn KaupJens SchraderJulia A. Vorholt
Here we discuss the history of CCRs in both primary and secondary metabolism, the mechanism by which they function, examples of new polyketide diversity from pathway specific CCRs, and the role of CCRs in facilitating the bioengineering novel polyketides.Wilson, M....