Ethylene glycol (EG) toxicity is commonly encountered in dogs and cats. Ethylene glycol is most commonly found in automotive antifreeze and is also used as a precursor to industrial polymers. It is a colorless, odorless, and sweet-tasting solution. After ingestion, the solution is rapidly ...
Many veterinarians are familiar with ethylene glycol toxicity because of the frequent cases in dogs and cats that have licked up radiator fluid. Initially, patients may be asymptomatic, but ethylene glycol is rapidly absorbed (within 1 to 4 hours), and altered mental status and tachypnea then ...
Veterinarians are often familiar with ethylene glycol toxicity because of cases involving dogs or cats that drank radiator fluid. Ethylene glycol itself has initial CNS effects resembling those of ethanol [21]. However, metabolism of ethylene glycol by alcohol dehydrogenase to glycolaldehyde is then ...
The clinical course of ethylene glycol toxicity occurs in three phases: Phase 1 is the neurologic phase, occurring 0.5 to 12 hours after ingestion and is characterized by the appearance of inebriation without the odor of alcohol on the patient's breath. Nausea, vomiting, and hematemesis ...
administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, EGdM, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate, and the toxicity was related to their chemical ...
Ethylene glycol is a colorless, odorless, sweet liquid, commonly found in antifreeze. Ethylene glycol may be drunk accidentally or intentionally in a suicide attempt. When broken down by the body, it results in glycolic acid and oxalic acid, which cause most of the toxicity. The diagnosis may...
Wistar male rats were exposed by inhalation to 50, 100 or 400 ppm of ethylene glycol monomethyl ether (EGME) for 1 or 2 weeks. The overall hepatic drug oxidation reactions, O-deethylation of 7-ethoxycoumarin and 7-ethoxyresorufin and cytochrome P-450 content were only slightly affected by ...
Several toxic alcohols are of medical and toxicological importance; the principal ones include ethanol, ethylene glycol (EG), methanol, and isopropanol. See Alcohol Toxicity.
A subacute toxicity study with administration of tetraethylene glycol in dosages of 0-220-660-2000 mg/kg body weight to male and female Wistar rats via gav... L.Schladt,I.Ivens,E.Karbe,... - 《Experimental & Toxicologic Pathology》 被引量: 0发表: 1998年 ...
These studies were performed to assess the chronic toxicity and oncogenicity of ethylene glycol (EG) in rats and mice. Groups of 130 Fischer 344 rats and 80 CD-1 mice per sex were fed diets yielding approximate dosages of 1.0, 0.2, or 0.04 g/kg/day of EG. Two separate control groups...