A new technical synthesis to produce ethyl ( R)-2-hydroxy-4-phenylbutyrate ( 5), an important intermediate for several ACE inhibitors with >99% ee in an over-all yield of 50–60% is described starting from acetophenone and diethyl oxalate. Key step is the chemo- and enantioselective ...
ETHYL 2-(R)-HYDROXY-4-PHENYLBUTYRATE CAS号: 英文名:ETHYL 2-(R)-HYDROXY-4-PHENYLBUTYRATE 中文名: CBNumber:CB9523535 分子式:C12H16O3 分子量:208.25364 MOL File:Mol file ETHYL 2-(R)-HYDROXY-4-PHENYLBUTYRATE上下游产品信息 上游原料 下游产品 ETHYL 2-(R)-HYDROXY-4-PHENYLBUTYRATE生产厂家 德国1...
英文别名 AKOS005259605 | DTXSID80370112 | Ethyl(R)-(-)-2-hydroxy-4-phenylbutyrate | SB79178 | SCHEMBL1351195 | 4-trifluoromethoxy-2-chloroaniline | 2-chloranyl-4-(trifluoromethyloxy)aniline | AM62082 | AC-3732 | SY050847 | EN300-173489 | PS-8002 | 2-CHLORO-4-TRIFL 规格或纯度 ≥...
ChemInform Abstract: An Efficient Synthesis of Ethyl (R)‐2‐Hydroxy‐4‐phenylbutyrate: A Useful Intermediate in the Synthesis of Converting Enzyme Inhibitors. 来自 Wiley 喜欢 0 阅读量: 31 作者:GA Flynn,DW Beight 摘要: The Grignard compound (IV) reacts with the optically active oxalate (III...
饰位上两部分的加氢速率9建立了不对称加氢的动力学模型9经拟合得到参数并进行了验证和讨论 关键词#不对称加氢;( R ) -2- 羟基 -4- 苯基丁酸乙酯;本征动力学 中图分类号# T 032 文献标识码# A 文章编号# 0438 1157 ( 2006 ) 01 0046 06 Kineticsofenantioselectiveh y dro 9 enationtos y nthesize ...
(R)-2-hydroxy-4-phenylbutyrateusingarecombinant E.coliwithhighcatalystyield YeNi ∗ ,YuningSu,HaidongLi,JieyuZhou,ZhihaoSun TheKeyLaboratoryofIndustrialBiotechnology,MinistryofEducation,SchoolofBiotechnology,JiangnanUniversity,Wuxi214122,Jiangsu,China articleinfo Articlehistory: Received19July2013 Receivedinrevi...
Ethyl 2-oxo-4-phenylbutyrate (OPBE) was purchased from Puyuan Chemical Co., Ltd. (Taicang, China). Ethyl (R/S)-2-hydroxyl-4-phenylbutanoate enantiomers [(R/S)-HPBE] were supplied by XHSynbio Co., Ltd. (Hangzhou, China). Nicotinamide adenine dinucleotide (NADH and NAD+) and isopropyl...
The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(EOPB) catalyzed by saccharomyces cerevisiae in organic phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(EHPB) was investigated.In diethyl ether with the initial EOPB concentration of 6 mmol·L-1,the e.e.(R)-EHPB was increased...
Lipase-catalyzed irreversible transesterification using enol esters: Resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (... Procedures for the resolution of several cyanohydrins of synthetic value via lipase-catalyzed kinetic resolution using enol esters as irreversible...
Catalytic Asymmetric Direct α-Amination Reactions of 2-Keto Esters: A Simple Synthetic Approach to Optically Active syn-β-Amino-α-hydroxy Esters. Examines the catalytic asymmetric direct alpha-amination reactions of 2-keto esters. Chemical reaction of ethyl 2-keto-4-phenylbutyrate with azo dicarbo...