Germ-cell gene therapy does not seek to cure a disease currently being suffered, rather it seeks to alter the individual's genome so that a disease-causing mutation will not be inherited by the individual's progeny. In this paper we will discuss the arguments in favor of gene therapy ...
success of the therapy was tentative, because along with the gene therapy the patients also continued receiving their traditional drug therapy. This made it difficult to determine the true effectiveness of the gene therapy on its own, as distinct from the effects of the more traditional therapy. ...
Contemporary medical and scientific knowledge in the field of gene therapy has the potential to inform us about many of the known inherited genetic conditions. In addition, medicine now has the ability to identify a significant number of diseases which may be inherited from us by our children. ...
The major scientific achievement of the Twentieth Century was the discovery of the double helix, and the mapping of the human genome in 2003. Contemporary medical and scientific knowledge in the field of gene therapy has the potential to inform us about many of the known inherited genetic ...
Clinical trials in vascular gene therapy: the missing piece of the puzzle. Vascular gene transfer provides unique opportunities for novel therapies for cardiovascular disease. To define the limitations and expectations of translat... RD Simari,T O'Brien - 《Archives of Pathology & Laboratory ...
JC Fletcher,G Richter - 《Human Gene Therapy》 被引量: 72发表: 1996年 Ethical issues in and beyond prospective clinical trials of human gene therapy. As the potential for the first human trials of somatic cell gene therapy nears, two ethical issues are examined: problems of moral choice for...
In the US, gene therapy companies, as with all biopharmaceutical companies, are not required by law or regulation to provide their investigational products to patients via non-trial preapproval (expanded) access. However, we believe that gene therapy companies, in particular, have a moral obligatio...
Ethical Issues in Molecular Screening for Heterozygous Familial Hypercholesterolemia: The Complexity of Dealing with Genetic Susceptibility to Coronary Artery Disease In addition, new technologies could be applied to FH, such as high-density DNA probe arrays and gene therapy. The use of genetic informati...
testing children for heritable genetic traits and diseases and v, gene therapy. While the promise of genetic technology is tremendous, it creates some especially difficult ethical and scientific problems. All physicians must be prepared to meet the ethical and scientific challenges of the new genetics...
Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cells. the treatment of Parkinson's disease, the use of human embryonic brain tissue as the source of transplants raises difficult ethical and practical problems... JA Gray...