Germ-cell gene therapy does not seek to cure a disease currently being suffered, rather it seeks to alter the individual's genome so that a disease-causing mutation will not be inherited by the individual's progeny. In this paper we will discuss the arguments in favor of gene therapy ...
When we discuss the ethics of gene therapy, a distinction should be made between somatic (non-reproductive) and germ (reproductive) cell therapies. In this article, we focus on the ethical issues related to prenatal screening for genetic disorders which include autonomy, cost and maternal anxiety...
of a deceased donor renal transplant to a geriatric patient while young patients continue waiting for a donor kidney; and (3) appreciating the concept of futility and support for a uremic patient opting for death rather than further uremia therapy as the best in choice in coping with renal ...
Ethical Issues in Molecular Screening for Heterozygous Familial Hypercholesterolemia: The Complexity of Dealing with Genetic Susceptibility to Coronary Artery Disease In addition, new technologies could be applied to FH, such as high-density DNA probe arrays and gene therapy. The use of genetic informati...
When we discuss the ethics of gene therapy, a distinction should be made between somatic (non-reproductive) and germ (reproductive) cell therapies. In this article, we focus on the ethical issues related to prenatal screening for genetic disorders which include autonomy, cost and maternal anxiety...
Ethical Issues in Human Gene Therapyby LeRoy Walters, Kennedy Institute of Ethics, Georgetown University The Ethics of Gene Therapyby Emilie R. Bergeson Video 3: The Ethics of Genetically Engineering Children (YouTube, 5:52) Video 4: Gene Therapy and Ethics (YouTube, 8:58) ...
ACMG Policy Statement © American College of Medical Genetics and Genomics Technical report: ethical and policy issues in genetic testing and screening of children Laine Friedman Ross, MD, PhD1–2, Howard M. Saal, MD3, Karen L. David, MD, MS4,6 and Rebecca R. Anderson, JD, MS5; and...
The genetic testing and genetic screening of children are commonplace. Decisions about whether to offer genetic testing and screening should be driven by the best interest of the child. The growing literature on the psychosocial and clinical effects of s
Expanded Access as a source of real-world data: An overview of FDA and EMA approvals Br. J. Clin. Pharmacol., 86 (2020), pp. 1819-1826 CrossrefView in ScopusGoogle Scholar 7 P. Colella, G. Ronzitti, F. Mingozzi Emerging issues in AAV-mediated in vivo gene therapy Mol. Ther. Me...
Patenting should be discouraged, (3) Gene therapy: The identification of a disease-specific gene should not be granted a product patent, but rather encourage the invention of safe and effective methods of gene delivery, and (4) Therapeutic proteins: Not the DNA sequence as such, but the ...