Technical Problems and Ethical Concerns Regarding Gene Editing in Human Germlines and Embryosdoi:10.18502/jri.v24i3.13270GENOME editingEMBRYOSSERIAL publicationsCELL linesHUMAN beingsSadeghi, Mohammad RezaJournal of Reproduction & Infertility
Biotechnology offers transformative advances in medicine, agriculture, and sustainability, yet raises serious ethical concerns, especially in stem cell research, cloning, and genetic engineering.
Moreover, we have presented an account on the recent ethical concerns raised with application of this technology in human germline editing and the future perspectives associated with the wise usage of this remarkable genome editing technology. 展开 ...
An overwhelming majority of the 182 articles addressed safety concerns associated with genetic errors or health implications. The high frequency of mutations jeopardizes the safety and efficacy of CRISPR germline editing, not only for the initially edited embryos but also for future offspring. Among th...
The principle of justice concerns fairness and equality. Specifications of this principle in the research context include laws against discrimination, the practice of disclosing conflicts of interest, the need for representative databases, and generalizable and reproducible results, as well as the taboo ...
The twofold distinction between interventions into the germ line and interventions into somatic cells on the one hand and between the treatment of diseases and enhancement on the other hand resulted in the concept of somatic gene therapy. There is a near
(Lander et al.,2019; Baltimore et al.,2015; Lanphier et al.,2015). Heritable human germline modifications are currently prohibited under various legislations (Baylis et al.,2020; Ledford,2015; Isasi et al.,2016; König,2017) and surveys show public concerns about such applications, ...
This is particularly important in the case of germline editing, because it's so unlike most conventional therapies.As the U.K. Nuffield Council has pointed out, it is incorrect to call it a therapy. If one were undertaking gene therapy in a baby, or even a fetus, to address a life-thr...
"The clinical application of humangermlinegene-editing is in the near future. We appeal topolicy-makersto pay serious attention to the relevant issues, actively confront the challenges and come up with a responsible and feasible pathway for clinical translation of human germline gene editing." ...
But such germline gene therapy doesn't only affect the individual germ cells or embryo that has been treated; any changes will be transmitted to the future children of that individual. This is highly controversial as it raises major safety concerns and the spectre of introducing "designer" mutati...