the main portion of the metabolism (>90%) occurs in the liver, where alcohol dehydrogenase reduces it to acetaldehyde.15 Although ethanol has some direct actions on the cardiovascular system, its main clinical action in acute intoxication is that of a central ...
To investigate the effects of chronic ethanol consumption on ethanol and drug metabolism, four alcoholic and four nonalcoholic volunteer subjects were given ethanol for one month under metabolic ward conditions. This resulted in accelerating the rate of disappearance of ethanol from the blood of the ...
Stimulants of ethanol metabolism, such as fructose, are not sufficiently effective, and use of analeptics is not recommended because of the possibility of precipitating convulsions.The immediate concern in the treatment of alcoholics is detoxification and management of the ethanol withdrawal syndrome. ...
Interestingly, LDLR-related protein (LRP) is involved in various cellular processes such as lipid metabolism, cell migration, and endocytosis30. Particularly, LRP1 activation inhibits Aβ aggregation31,32 and down-regulates NF-κB-dependent proinflammatory cytokines33,34, which are critical for AD ...
Studies have shown that androgen and estrogen can affect glucose/lipid metabolism in peripheral organs (e.g., the liver) through differential regulation of the HPA axis43,44. Therefore, this sex disparity in metabolic programming by PEE was probably related to the effects of sex hormones on ...
Ethanol and acetaldehyde (AcH) metabolism were studied in male Caucasian alcoholic subjects and matched controls following 1 g/kg ethanol, which was administered after a 10 day, ethanol-free period. The rate of ethanol elimination was higher (p>0.05) in the alcoholics (0.120 g/kg/hr) than ...
converting excess NADPH to NADH. Higher PPP flux explains the glucose–xylose co-utilization and overall higher sugar consumption rate of strain SCD78 compared to SCD00. Higher sugar consumption requires higher sugar transport and a higher metabolism rate. If the downstream metabolism is slower than...
alcohol dehydrogenase and pyruvate decarboxylase, further comprises DNA encoding proteins which enable the host to transport and metabolize an oligosaccharide. The host expresses the DNA at a level such that the host produces ethanol as a primary fermentation product from the metabolism of the ...
Ethanol effects on excitation-contraction coupling, oxidative stress, apoptosis, and cardiac metabolism, as well as effects of ethanol metabolites will be discussed. Important recent findings have been gained by investigation of acute ethanol effects. These include a renewed focus on reactive oxygen ...
In fact, the rate of ethanol metabolism as measured by the slope of the curves, was not significantly different between GR7-scr- and GR7-shRNA-injected rats (main effect of viral injection: F(1,7) ¼ 0.024, p ¼ 0.882). More importantly the interaction between viral injection and ...