testosterone therapythrombotic risktransdermal administrationvenous thromboembolismSummary The thrombogenic effects of estrogen relate to the route of administration as well as the dose. The thrombotic risk appears to be reduced with the parenteral or transdermal administration of estrogen. Exposure of the ...
Clarifications obtained with knockout mice models as well as some clinical investigations showed that estrogen receptors significantly influenced the overall maintenance of the testis functions through aromatase activity, intervening in the testosterone production by the Leydig cells and, indirectly with the ...
SLE.This difference in estradiol levels was not found in males, though it should be noted that there are not as many large studies on SLE in men. This implies that there is a higher-than-normal conversion of testosterone to estrogen. Plus, it might amplify estrogen’s effect in the body...
of these observed beneficial effects, the FDA has not yet approved the use of testosterone for women for sexual indications because of the short-term duration of all of these studies (24 weeks); clinicians electing to treat do so off-label and must use testosterone products formulated for men...
As previously shown13, male AROM+ mice have significantly higher estradiol and lower testosterone levels compared to wild type (WT) male mice. Furthermore, pharmacological inhibition of the aromatase activity resulted in the anticipated normalization of the hormone levels (Fig. 1A). Thus, the male...
(37.2% men vs. 29.4% women), but men have a lower prevalence of HTN than women in adults older than 60 years (58.5% men vs. 66.8% women) [7]. Therefore, aging is characterized by increases in blood pressure (BP) in both men and women, reaching 63.1% among adults aged 60 ...
Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS. Here we show that gut microbiome mediates the preventive effect of estrogen
A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab. 2000;85(8):2832-2838.PubMedGoogle Scholar 34. Ambler DR, Bieber EJ, Diamond MP. Sexual function in elderly ...
Retinoic acid stimulates 17β-estradiol and testosterone synthesis in rat hippocampal slice cultures. Endocrinology 2009, 150, 4260–4269. [Google Scholar] [CrossRef] [Green Version] Biyong, E.F.; Tremblay, C.; Leclerc, M.; Caron, V.; Alfos, S.; Helbling, J.-C.; Rodriguez, L.; ...
What’s more, these same cells have the ability to convert testosterone into estrogen through an enzyme called aromatase. This is true for both men and women. It may be something to pay attention to for women in the menopausal years. As the ovaries decrease and then cease estrogen production...