Color code indicates the number of cohorts (four in total) in which this gene is also identified as a significantly upregulated target in ESR1 mutant samples. B Scatter plot showing the correlation of average regulatory per- centile between ESR1 mutant and estrogen treatment of 25 targets in (...
Statistical significance of was assessed by a 1,000-time permutation test with respect to modulator status for each gene pair. Simulation study We synthesized a total of 45 simulated datasets, each dataset was constructed using a specific sample size (N = 30, 100, 300, 500, or 1,000)...
Statistical significance of ∆IMI was assessed by a 1,000-time permutation test with respect to modulator status for each gene pair. Simulation study. We synthesized a total of 45 simulated datasets, each dataset was constructed using a specific sample size (N = 30, 100, 300, ...