estrogen response element(ERE) 专业医学词典 雌激素效应元件 与"estrogen response element(ERE)"相近的词条 ... estrogen receptor protein Estrogen receptor site estrogen receptor(ER) estrogen replacement therapy estrogen response element estrogen response element(ERE) estrogen-secreting tumor estrogen-stimulated...
网络雌激素效应元件;雌激素应答元件 网络释义
Estrogen receptorsact mainly by regulating the expression of target genes whose promoters contain specific sequences called estrogen-responsive element (ERE). After ERE-binding of ligand-boundERdimers, modulation of transcription occurs via interaction with coactivators or corepressors. All together, these...
estrogen response element-binding protein Basic information More.. Product Name: estrogen response element-binding protein Synonyms: estrogen response element-binding protein CAS: MF: MW: 0 EINECS: Mol File: Mol File Information Error Report Your Email: Browse by province estrogen response ...
However, the binding was not affected by the uterine extract, indicating that the heat sensitive nuclear factors may interact with the hER outside the DBD to enhance the binding of ER to ERE. 展开 关键词: Nuclear factors estrogen receptor estrogen response element ...
et al. Binding of estrogen receptor βto estrogen response element in situ is independent of estradiol and impaired by its amino terminus. Mol. Endocrinol. 19, 2696–712 (2005). 27. Berry, M., Nunez, A. & Chambon, P. Estrogen-responsive element of the human pS2 gene is an ...
We have obtained evidence that purification of ER removes an accessory protein(s) that interacts with ER in a sequence- and/or DNA conformational-dependent manner, resulting in stabilization of E2, but not 4-OHT, in the ligand binding domain when the receptor binds to DNA. We postulate that...
In this first report, we examine the genome-wide chromatin localization of an altered-specificity mutant ER with a DNA binding domain deficient in binding to estrogen response element (ERE)-containing DNA (DBDmut ER) versus wild-type ERα. Using high-throughput sequencing of ER chrom...
This structural alteration generates binding surfaces for effective interactions with co-regulatory proteins, enhances the stability and the association with DNA of the ERα dimer2,3,4,5,6,7. The nuclear E2-bound ERα regulates gene transcriptions through estrogen response element (ERE)-dependent ...