estrogen receptor negative estrogen receptor positive estrogen receptor status estrogen replacement therapy estrogenic Estrogen-receptor assay estrogen-responsive tissue Estrogens estrogens, conjugated estrogens, esterified estrone estrone unit estrophilin estropipate Estrostep estrous estrous cycle estrual estruatio...
(as of the breast, uterus, or bone) and act as agonists to enhance estrogen activity in some tissues and as antagonists to inhibit estrogen activity in other tissues see the full definition word of the day numinous see definitions and examples » get word of the day daily email! test you...
The meaning of ESTROGEN is any of various natural steroids (such as estradiol) that are formed from androgen precursors, that are secreted chiefly by the ovaries, placenta, adipose tissue, and testes, and that stimulate the development of female secondar
Recent studies reviled that these ESR1 mutations lead to constitutive activity of the estrogen receptor ER, meaning that the receptor is active in absence of its ligand conferring resistance against endocrine therapy and tumor growth. Published studies have not yet been able to determine the exact ...
These compounds are aimed to inhibit the production of E2 in postmenopausal women; thus, a current clinical usage of anastrozole, exemestane, and letrozole as they became useful in the management of patients with breast cancer lesions found to be E2 receptor positive. Aromatase inhibitors are also...
the full meaning of CRGS is ‘Cellular Response to Glucose Stimulus’; and the full meaning of IERSP is ‘Intracellular Estrogen Receptor Signaling Pathway’. The pathways are categorized into several types, and the MSigDB database from which the pathway is sourced is indicated in parentheses.bA...
When we have ample amounts of activated vitamin D, it binds with its receptor to regulate genes in our reproductive system. For example, activated vitamin D in the female reproductive system controls the genes involved in estrogen production. Vitamin D also regulates several genes during the proce...
Meaning The combination of clinical and molecular information may enhance the prognostic value for distant recurrence and risk stratification in estrogen receptor–positive, ERBB2-negative breast cancer, particularly for women with node-positive disease. Abstract Importance Multiple molecular signatures are av...
Patients With Breast Cancer Nicolò Matteo Luca Battisti, MD; Amelia McCartney, MBBS; Laura Biganzoli, MD JAMA Oncology Key Points Question Is receipt of adjuvant chemotherapy associated with survival in elderly patients with multiple comorbidities and node-positive, estrogen receptor–positive breast ...
Concomitantly, receptor status becomes an invasive part of the prognosis of breast cancer. Many aromatase inhibitors inhibit the receptors from binding with estrogen, while others inhibit the actual aromatase enzymes that function to convert androgens to estrogens. In addition, aromatase inhibitors lower ...